Results 31 to 40 of about 2,894 (131)
Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany. [PDF]
PLoS ONE, 2014 Human metapneumovirus (HMPV) is a cause of respiratory tract illness at all ages. In this study the epidemiological and molecular diversity among patients of different ages was investigated. Between 2000-2001 and 2009-2010, HMPV was detected in 3% (138/4,
Janine Reiche +7 more
doaj +1 more source
The Prevalence and Genetic Characterization of Human Metapneumovirus in Bulgaria, 2016–2019
Intervirology, 2021 Introduction: We investigated the prevalence of human metapneumovirus (hMPV) among patients with acute respiratory infections in Bulgaria, and performed genetic characterization of the F gene of these strains. Methods: Nasopharyngeal swabs collected from
Neli S. Korsun +7 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, Volume 20, Issue 11, Page 2820-2838, November 2026.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2013 (A) M-hMPV protein was captured in the supernatant of the infected Vero cells by using positively charged magnetic beads. Samples were incubated with 1 µg/mL monoclonal antibodies directed against M-hMPV and 1 µg/mL goat anti-mouse immunoglobulin G ...
Guy Vernet (174407) +8 more
core +1 more source
Zhongguo gonggong weisheng, 2023 ObjectiveTo analyze genetic characteristics of human metapneumovirus (hMPV) strains isolated in Ningxia Hui Autonomous Region (Ningxia) for providing relevant data to construct hMPV genome database in China.
Xinning WANG +6 more
doaj +1 more source
RPM-1, but not wild-type HMPV F, binds neutralizing antibodies to both RSV and HMPV.
, 2016 (a, b) Binding of the anti-HMPV F DS-7 antibody to wild-type (a) and RPM-1 (b) proteins. Both HMPV F proteins bound with similar affinity to the antibody demonstrating that the DS-7 epitope is not affected by the RPM-1 mutations.
Xiaolin Wen (2806171) +6 more
core +1 more source
Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway
Virus ResearchBackground: Human metapneumovirus(hMPV) is one of the most common viruses that cause acute lower respiratory tract infections. Interleukin-1β (IL-1β) has been reported to play an important role in multiple virus replication.
Guojin Wu +5 more
doaj +1 more source
Multiple infections detected with HMPV.
, 2017 Multiple infections detected with HMPV.
Maria del Mar Molinero (3841918) +6 more
core +1 more source
Structural basis for childhood antibody recognition of the human metapneumovirus fusion protein
Nature CommunicationsHuman metapneumovirus (hMPV) is a significant cause of acute respiratory illness in children and older adults, with most children becoming seropositive by five years of age.
Ahmed Magdy Khalil +7 more
doaj +1 more source
PLoS Pathogens, 2019 NOD-like receptor protein 3 (NLRP3) inflammasome activation triggers caspase-1 activation-induced maturation of interleukin (IL)-1β and IL-18 and therefore is important for the development of the host defense against various RNA viral diseases.
Vuong B Lê +8 more
doaj +1 more source