Results 181 to 190 of about 239,936 (333)

Towards a predictive systems-level model of the human microbiome: progress, challenges, and opportunities [PDF]

, 2013
Sharon Greenblum, Hsuan-Chao Chiu, Roie Levy, Rogan Carr, Elhanan Borenstein   +4 more
openalex   +1 more source

Fighting Antibiotic Resistance: Insights Into Human Barriers and New Opportunities

BioEssays, EarlyView.
Antibiotic resistance is a public health issue leading to the emergence of multi‐resistant bacteria. Human‐dependent factors are now driving the increase of resistance, notably through antibiotic misuse in human and animal health and environmental pollution.
Aubin Pitiot, Camille Rolin, Carole Seguin‐Devaux, Jacques Zimmer   +3 more
wiley   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Need for Prospective Cohort Studies to Establish Human Gut Microbiome Contributions to Disease Risk [PDF]

, 2013
Volker Mai, J. Glenn Morris
openalex   +1 more source

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Molecular Research in Human Microbiome. [PDF]

Int J Mol Sci, 2023
Mascellino MT.
europepmc   +1 more source

Structure and function of the human skin microbiome [PDF]

, 2013
Nina N. Schommer, Richard L. Gallo
openalex   +1 more source

Cold‐Adapted Lipid A from Polaribacter sp. SM1127: A Study of Structural Heterogeneity and Immunostimulatory Properties

ChemBioChem, EarlyView.
This analysis reveals structural heterogeneity in the lipopolysaccharide lipid A from the cold‐adapted Gram‐negative bacterium Polaribacter sp. SM1127, with variations in fatty acid chain number, length, branching, saturation, and hydroxylation degree, likely aiding bacterial adaptation to cold environmental stressors. Lipopolysaccharide is shown to be
Roberta Cirella, Emanuela Andretta, Luca De Simone Carone, Francesca Olmeo, Mei‐Ling Sun, Yu‐Zhong Zhang, Marcello Mercogliano, Antonio Molinaro, Alba Silipo, Flaviana Di Lorenzo   +9 more
wiley   +1 more source

The Human Microbiome in Intensive Care - A Journey Forward? [PDF]

J Crit Care Med (Targu Mures), 2023
Azamfirei L.
europepmc   +1 more source