Results 211 to 220 of about 8,462,270 (351)

Structure of the gut microbiome following colonization with human feces determines colonic tumor burden [PDF]

, 2014
Nielson T. Baxter, Joseph P. Zackular, Grace Chen, Patrick D. Schloss   +3 more
openalex   +1 more source

Discovery of a Phenylalanine‐derived Natural Compound as a Potential Dual Inhibitor of MDM2 and MDMX

ChemMedChem, Accepted Article.
Dual inhibition of the negative p53 regulators MDM2 and MDMX has emerged as an effective strategy in p53‐based anticancer therapy. However, dual inhibitors are limited, and many inhibitors exhibit poor pharmacokinetic properties and fast dissociation kinetics.
JA YOUNG CHO, Sanghwa Park, Taejung Kim, Junghye Eom, Jung-Rae Rho, Hyoung-Woo Bai   +5 more
wiley   +1 more source

Advances in human microbiome and prostate cancer research. [PDF]

Front Immunol
Pei X, Liu L, Han Y.
europepmc   +1 more source

Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa [PDF]

, 2014
Liang Ma, Jung-Woo Kim, Roland Hatzenpichler, Mikhail A. Karymov, Nathaniel Hubert, Ira M. Hanan, Eugene B. Chang, Rustem F. Ismagilov   +7 more
openalex   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

The human microbiome: redefining cancer pathogenesis and therapy. [PDF]

Cancer Cell Int
Adlakha YK, Chhabra R.
europepmc   +1 more source

16S rRNA gene sequencing data from the Human Microbiome Project used to assess microbial co-occurrence relationships in the human microbiome.

, 2012
Karoline Faust, Fah Sathirapongsasuti J., Izard Jacques, Segata Nicola, Dirk Gevers, Raes Jeroen, Curtis Huttenhower   +6 more
openalex   +1 more source

mtDNA haplogroup and single nucleotide polymorphisms structure human microbiome communities [PDF]

, 2014
Jun Ma, Cristian Coarfa, Xiang Qin, Penelope E. Bonnen, Aleksandar Milosavljevic, James Versalovic, Kjersti M. Aagaard   +6 more
openalex   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Role of Human Microbiome in Development and Management of Head and Neck Squamous Cell Carcinoma. [PDF]

Cancers (Basel)
Palkovsky M, Modrackova N, Neuzil-Bunesova V, Liberko M, Hlodakova A, Soumarova R.   +5 more
europepmc   +1 more source