Results 221 to 230 of about 180,411 (308)

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Awareness of human microbiome may promote healthier lifestyle and more positive environmental attitudes. [PDF]

Commun Med (Lond)
Rook O, Zwart H.
europepmc   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

The Human Microbiome as a Therapeutic Target for Metabolic Diseases. [PDF]

Nutrients
Bui TPN.
europepmc   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Bibliometric and visual analysis of human microbiome-breast cancer interactions: current insights and future directions. [PDF]

Front Microbiol
Zhou Y, Jiang M, Li X, Shen K, Zong H, Lv Q, Shen B.   +6 more
europepmc   +1 more source

The Influence of Omega‐3 Fatty Acids and Probiotics on Hippocampal Inflammation and Glial Cells in a Chronic Anorexia Nervosa Rat Model

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with brain volume reduction, glial cell loss, microbiome alterations, and dysregulated pro‐inflammatory mechanisms. However, the underlying cellular mechanisms remain inadequately elucidated, and interventions addressing these alterations are lacking.
A. C. Thelen, N. Andreani, N. M. Korten, M. Neumann, V. Verspohl, M. van Egmond, L. Kneisel, C. Voelz, L. Blischke, J. F. Baines, J. Baier, J. Schumacher, F. Kiessling, B. Herpertz‐Dahlmann, C. Beyer, L. Keller, J. Seitz, S. Trinh   +17 more
wiley   +1 more source

Sample Size Estimations Based on Human Microbiome Temporal Stability Over 6 Months: A Shallow Shotgun Metagenome Sequencing Analysis. [PDF]

Cancer Epidemiol Biomarkers Prev
Zouiouich S, Wan Y, Vogtmann E, Porras C, Abnet CC, Shi J, Sinha R.   +6 more
europepmc   +1 more source

Prevotella are major contributors of sialidases in the human vaginal microbiome [PDF]

Paula Pelayo, Fatima A. Hussain, Caroline A. Werlang, Chloe M. Wu, Benjamin M. Woolston, Claire M. Xiang, Lindsay Rutt, Michael France, Jacques Ravel, Katharina Ribbeck, Douglas S. Kwon, Emily P. Balskus   +11 more
openalex   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source