Results 101 to 110 of about 564,378 (281)
Microbiome, 2019 The National Institutes of Health (NIH) is the primary federal government agency for biomedical research in the USA. NIH provides extensive support for human microbiome research with 21 of 27 NIH Institutes and Centers (ICs) currently funding this area ...
NIH Human Microbiome Portfolio Analysis Team
doaj +1 more source
Integrating citizen science with online learning to ask better questions [PDF]
arXiv, 2016 Online learners spend millions of hours per year testing their new skills on assignments with known answers. This paper explores whether framing research questions as assignments with unknown answers helps learners generate novel, useful, and difficult-to-find knowledge while increasing their motivation by contributing to a larger goal.
arxiv
Advanced Science, EarlyView.XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue +15 more
wiley +1 more source
Modeling association in microbial communities with clique loglinear models [PDF]
arXiv, 2018 There is a growing awareness of the important roles that microbial communities play in complex biological processes. Modern investigation of these often uses next generation sequencing of metagenomic samples to determine community composition. We propose a statistical technique based on clique loglinear models and Bayes model averaging to identify ...
arxiv
Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population
Advanced Science, EarlyView.This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen +16 more
wiley +1 more source
Metabolome and microbiome in kidney diseases
Saudi Journal of Kidney Diseases and Transplantation, 2020 Despite several decades of intensive research and hard work in nephrology, a void exists in the availability of markers for identifying at-risk individuals, diagnosing diseases at incipient stage, and predicting treatment response.
R Vairakkani +2 more
doaj +1 more source
A Bayesian Zero-Inflated Negative Binomial Regression Model for the Integrative Analysis of Microbiome Data [PDF]
arXiv, 2018 Microbiome `omics approaches can reveal intriguing relationships between the human microbiome and certain disease states. Along with the identification of specific bacteria taxa associated with diseases, recent scientific advancements provide mounting evidence that metabolism, genetics and environmental factors can all modulate these microbial effects.
arxiv
Image and graph convolution networks improve microbiome-based machine learning accuracy [PDF]
arXiv, 2022 The human gut microbiome is associated with a large number of disease etiologies. As such, it is a natural candidate for machine learning based biomarker development for multiple diseases and conditions. The microbiome is often analyzed using 16S rRNA gene sequencing.
arxiv
Advanced Science, EarlyView.This study presents a novel polyphenol‐nanozyme‐armored probiotic system (ECA@EcN) for enhanced treatment of inflammatory bowel disease (IBD). By integrating chitosan‐modified epigallocatechin gallate (EGCG‐CS) with gold nanozymes, the system effectively scavenges ROS, improves probiotic viability, and restores gut microbiota balance.
Yong Zhu +12 more
wiley +1 more source
Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother.
Fabia de Oliveira Andrade +2 more
wiley +1 more source