Functional Synovium‐Based 3D Models in the Context of Human Disease and Inflammation
The synovium is key to joint function but is often affected by diseases like rheumatoid arthritis. Finding better treatments is challenging because current lab models do not fully mimic real tissues. New 3D technologies, like bioprinting, offer better methods to study these diseases, improve drug testing, and develop personalized treatments, bringing ...
Amelia Heslington+3 more
wiley +1 more source
Docking results showed Resveratroloside had the highest Vina score, indicating that it was the most active and might be employed as a lead molecule for further structural modification. The possible action process of TMA‐Lyase lead compound was described, which further affects the occurrence and development of CHD.
Jincai Li+3 more
wiley +1 more source
Graph-based variant discovery reveals novel dynamics in the human microbiome [PDF]
Sequence differences between the strains of bacteria comprising host-associated and environmental microbiota may play a role in community assembly and influence the resilience of microbial communities to disturbances. Tools for characterizing strain-level variation within microbial communities, however, are limited in scope, focusing on just single ...
arxiv
Conditional regression based on a multivariate zero-inflated logistic normal model for microbiome relative abundance data [PDF]
The human microbiome plays critical roles in human health and has been linked to many diseases. While advanced sequencing technologies can characterize the composition of the microbiome in unprecedented detail, it remains challenging to disentangle the complex interplay between human microbiome and disease risk factors due to the complicated nature of ...
arxiv
Isolation and purification of Tartary buckwheat polysaccharides and their effect on gut microbiota
The Tartary buckwheat polysaccharides present in different fractions had specific probiotic effects. The composition of gut microbiota was significantly altered by adding Tartary buckwheat polysaccharides during fecal fermentation. Tartary buckwheat can provide specific dietary polysaccharide sources to modulate and maintain gut microbiota diversity ...
Yue Xiang+7 more
wiley +1 more source
Describing the Persistence Landscape for Introducing Microbes into Complex Communities [PDF]
The introduction of non-native organisms into complex microbiome communities holds enormous potential to benefit society. However, microbiome engineering faces several challenges including successful establishment of the organism into the community, its persistence in the microbiome to serve a specified purpose, and constraint of the organism and its ...
arxiv
Latent Variable Modeling for the Microbiome [PDF]
The human microbiome is a complex ecological system, and describing its structure and function under different environmental conditions is important from both basic scientific and medical perspectives. Viewed through a biostatistical lens, many microbiome analysis goals can be formulated as latent variable modeling problems.
arxiv
Massive Multi-Omics Microbiome Database (M3DB): A Scalable Data Warehouse and Analytics Platform for Microbiome Datasets [PDF]
Massive Multi-Omics Microbiome Database (M3DB) is a data warehousing and analytics solution designed to handle diverse, complex, and unprecedented volumes of sequence and taxonomic classification data obtained in a typical microbiome project using NGS technologies.
arxiv
Global demand to reduce polymer waste and microplastics pollution has increased in recent years, prompting further research, development, and wider use of biodegradable and biobased polymers (BBPs). BBPs have emerged as promising alternatives to conventional plastics, with the potential to mitigate the environmental burdens of persistent plastic waste.
Sara T. R. Velasquez+5 more
wiley +1 more source
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu+11 more
wiley +1 more source