Results 171 to 180 of about 564,378 (281)

Charting the landscape of the environmental exposome

iMeta, Volume 1, Issue 4, December 2022., 2022
We describe the biological and chemical components of the environmental exposomes in three major environmental matrices that are highly relevant to human and social‐economical health—air, soil, and water. We discuss how different exposome components can interact with each other. Finally, we propose a list of outstanding challenges to be tackled to push
Xin Wei, Zinuo Huang, Liuyiqi Jiang, Yueer Li, Xinyue Zhang, Yuxin Leng, Chao Jiang   +6 more
wiley   +1 more source

Distinct Patterns of Dynamical Regulation in Passive Sensor Data Following Binge and Purge Behaviors

International Journal of Eating Disorders, EarlyView.
ABSTRACT Background Binge eating is a cardinal symptom of binge‐eating disorder (BED) and bulimia nervosa (BN), while recurrent purging is specific to BN (American Psychiatric Association, 2022). These behaviors are associated with health consequences (e.g., gastrointestinal, cardiovascular, and metabolic problems; Sheehan & Herman, 2015). The distress‐
Jonathan E. Butner, Laura M. Thornton, Robyn E. Kilshaw, Rachael E. Flatt, Qinxin Shi, Pascal R. Deboeck, Jenna Tregarthen, Stuart Argue, Brian R. W. Baucom, Cynthia M. Bulik   +9 more
wiley   +1 more source

Metabolite profiling of human‐originated Lachnospiraceae at the strain level

iMeta, Volume 1, Issue 4, December 2022., 2022
The human‐originated Lachnospiraceae biobank included 77 species was constructed. In vitro metabolite profiling of 110 Lachnospiraceae strains yielded 242 metabolites of 17 categories. Many Lachnospiraceae strains produce short‐chain fatty acids, and Agathobacter rectalis strain Lach‐101 and Coprococcus comes strain NSJ‐173 are the top two butyric acid
Rashidin Abdugheni, Wen‐Zhao Wang, Yu‐Jing Wang, Meng‐Xuan Du, Feng‐Lan Liu, Nan Zhou, Cheng‐Ying Jiang, Chang‐Yu Wang, Linhuan Wu, Juncai Ma, Chang Liu, Shuang‐Jiang Liu   +11 more
wiley   +1 more source

Antibiotic‐Induced Microbial Dysbiosis Worsened Outcomes in the Activity‐Based Anorexia Model

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a complex psychiatric disorder characterized by persistent dieting and reduced food intake, leading to significantly low body weight. Dysbiosis in the gut microbiome of patients with AN has been suggested to contribute to the pathogenesis.
Karlijn L. Kooij, Nadia Andrea Andreani, Lara Keller, Stefanie Trinh, Luna van der Gun, Jamie Hak, Keith Garner, Mieneke Luijendijk, Lisa Drost, Unna Danner, Annemarie van Elburg, Astrid Dempfle, Jochen Seitz, Beate Herpertz‐Dahlmann, John F. Baines, Roger A. H. Adan   +15 more
wiley   +1 more source

Targeting keystone species helps restore the dysbiosis of butyrate‐producing bacteria in nonalcoholic fatty liver disease

iMeta, Volume 1, Issue 4, December 2022., 2022
In this study, we applied an algorithm to the keystone species identification in the gut microbiome, based on current causal inference theories and the dynamic intervention simulation. We identified the nonalcoholic steatohepatitis (NASH) keystone species combination, represented by Porphyromonas loveana, Alistipes indistinctus, and Dialister ...
Dingfeng Wu, Lei Liu, Na Jiao, Yida Zhang, Li Yang, Chuan Tian, Ping Lan, Lixin Zhu, Rohit Loomba, Ruixin Zhu   +9 more
wiley   +1 more source

Dietary fiber chemical structure determined gut microbiota dynamics

iMeta, Volume 1, Issue 4, December 2022., 2022
The monosaccharide composition and glycosidic bond configuration determine the CAZyme that could hydrolyze it. Thus, bacteria encoding specific CAZyme utilize different structured dietary fibers. Compounded with bacterial interaction, gut microbiota dynamics is synergistically modulated.
Xin Meng, Jun Zheng, Fengqiao Wang, Jie Zheng, Dong Yang   +4 more
wiley   +1 more source

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Cancer Communications, EarlyView.
Lea Järke, Saskia Weber‐Stiehl, Kensuke Shima, Karlis Arturs Moors, Jerome Genth, Fenja Amrei Schuran, Lena Best, Markus Tschurtschenthaler, Burkhardt Flemer, Silke Lüschen, Christoph Röcken, Andreas Tholey, Christoph Kaleta, Jan Rupp, Philip Rosenstiel, Felix Sommer   +15 more
wiley   +1 more source

Gut microbiota and risk of heart failure in European population—A comprehensive Mendelian randomization study

ESC Heart Failure, EarlyView.
Abstract Aims Gut dysbiosis is proven to be involved in the pathogenesis and progression of heart failure (HF). Hindering the detrimental effects of gut‐heart axis is an emerging trend. Our goal is to investigate the causal relationship between gut microbiota and HF, with the aim of facilitating future exploration of microbiome‐targeted approaches to ...
Liyan Huang, Xuemei Zhao, Jing Wang, Jingyuan Guan, Boping Huang, Jiayu Feng, Xinqing Li, Yuhui Zhang, Jian Zhang   +8 more
wiley   +1 more source

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source

Deciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning

Exploration, EarlyView.
The causal relationship between gut microbiota and brain tumors and potential prognostic value of microbiota are still unclear. This study confirmed the causal effects of specific gut microbiota on three common brain tumors and identified microbe‐related genes that are expressed in brain tissue and correlated with the abundance of gut microbiota ...
Changwu Wu, Fushu Luo, Yongye Zhu, Chunbo Liu, Zheng Chen, Xiangyu Wang, Jun Tan, Qing Liu   +7 more
wiley   +1 more source