Results 201 to 210 of about 133,927 (289)

The impact of a high‐fat diet on liver health in pregnant mice and their offspring: The role of the gut‐liver axis

open access: yesiMetaOmics, EarlyView.
The study investigated the longitudinal effects of normal and high‐fat diet, showing their differential effects on gut microbiota diversity and gut metabolites, with the latter having a significant impact on increasing liver inflammation and gut microbiota and metabolites disruption.
Qian Gong   +7 more
wiley   +1 more source

Longitudinal profiling of the human gut microbiome reveals temporal and personalized responses to inulin

open access: yesiMetaOmics, EarlyView.
This study monitored gut microbiome changes in healthy volunteers following inulin intervention, revealing dynamic and highly individualized shifts in microbial composition and short‐chain fatty acid production. Using in vitro batch cultures, correlation analysis, and predictive modeling, we explored the personalized microbiome response.
Lu Wu   +7 more
wiley   +1 more source

Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs

open access: yesiMetaOmics, EarlyView.
This study successfully established gut microbiota‐humanized pigs, achieved human‐like remodeling of the serum metabolome, and uncovered transcriptional alterations in immune cell subsets. These findings advance our understanding of how human gastrointestinal microorganisms affect host metabolism and the immune function in a porcine model.
Zhaoqi Zhang   +9 more
wiley   +1 more source

BioMGCore: A toolkit for detection of biological metabolites in microbiome

open access: yesiMetaOmics, EarlyView.
The keyword matching and gene proximity principles were used to accurately identify core gene clusters in microbial genomes. The metabolic gene clusters can be classified into different taxonomic groups according to Domain, Phylum, Class, Order, Family, Genus, and Species. BioMGCore can achieve batch statistics for secondary metabolites prediction.
Guang Yang   +5 more
wiley   +1 more source

Group-wise normalization in differential abundance analysis of microbiome samples. [PDF]

open access: yesBMC Bioinformatics
Clark-Boucher D   +6 more
europepmc   +1 more source

Modular automated high‐throughput isolation and phylogenetic identification of bacteria from complex microbiomes

open access: yesiMetaOmics, EarlyView.
Metagenomic analysis can generate hypotheses about microbiome interactions and function, yet mechanistic understanding is only possible through precise experimentation manipulating its microbiota composition. The high‐throughput isolation of microbiome members thus represents a core resource in this field of research.
Rubén Chaboy‐Cansado   +6 more
wiley   +1 more source

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