Results 231 to 240 of about 564,378 (281)

Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example

open access: yesiMeta, EarlyView.
We present an innovative methodology that integrates core enzyme identification, protein structural characterization, regulator virtual screening, and functional validation to achieve precise microbiome functional regulation. As a proof of concept, we focused on the regulation of urea decomposition by the rumen microbiota in ruminants. This methodology
Shengguo Zhao   +9 more
wiley   +1 more source

Agriculture increases potential health risks of vertebrate viruses in soils

open access: yesiMeta, EarlyView.
Here, we conducted a large‐scale investigation of vertebrate viruses in soils and found soil was a mediator of vertebrate viruses. Compared to natural soils, agricultural soils possessed distinct prevalence patterns, with a higher detection rate and richness for vertebrate viruses and higher potential health risks.
Kankan Zhao   +5 more
wiley   +1 more source

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

open access: yesiMeta, EarlyView.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen   +21 more
wiley   +1 more source

Analysis of global trends and hotspots of skin microbiome in acne: a bibliometric perspective. [PDF]

open access: yesBioData Min
Zhang L   +11 more
europepmc   +1 more source

Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure

open access: yesiMeta, EarlyView.
Prenatal prednisone therapy (PPT)/prenatal prednisone exposure (PPE) induces long bone dysplasia, reduced peak bone mass (PBM), and increased osteoporosis susceptibility in female offspring. Maternal gut microbiota metabolite daidzein (DAI) mediates PPE‐induced osteoporosis susceptibility in female adult offspring.
Chi Ma   +13 more
wiley   +1 more source

Gut microbiota‐derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell differentiation

open access: yesiMeta, EarlyView.
This study explored the effect of plant‐derived indigo supplementation on intestinal inflammation using in vivo, in vitro, and clinical sample analyses. Our results showed that indigo decreased mucosal inflammation by regulating CD4+ T cell differentiation in a gut microbiota‐dependent manner.
Yunqi Xing   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy