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The Human Microbiome Project: lessons from human genomics [PDF]

Trends in Microbiology, 2011
The Human Microbiome Project (HMP) is following in the footsteps of the Human Genome Project (HGP), which will include exciting discoveries, but also potential disappointment and resentment over the lack of medical applications. There is a wiser path for the HMP.
Cecil M. Lewis, Alexandra J. Obregón-Tito, Raúl Y. Tito, Morris W. Foster, Paul G. Spicer   +4 more
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The Human Microbiome Project in 2011 and Beyond [PDF]

Cell Host & Microbe, 2011
The human microbiome comprises the genes and genomes of the microbiota that inhabit the body. We highlight Human Microbiome Project (HMP) resources, including 600 microbial reference genomes, 70 million 16S sequences, 700 metagenomes, and 60 million predicted genes from healthy adult microbiomes.
Lita M. Proctor
openalex   +5 more sources

The Integrative Human microbiome project: a mile stone in the understanding of the gut microbiome [PDF]

Expert Review of Gastroenterology & Hepatology, 2020
In the past several years, innovative technologies have allowed for the identification and quantification of the human microbiome composition and function [1].
Elida Voth, Sahil Khanna
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A data analysis and coordination center for the human microbiome project [PDF]

Genome Biology, 2010
The Human Microbiome Project (HMP) was launched by the National Institutes of Health (NIH) Roadmap for Medical Research and is designed to fuel research into the microbes that live in the various environments of the human body [1]. A major goal of the HMP is to look for correlations between changes in the microbiome and human health.
Jennifer R. Wortman, Michelle Giglio, Heather H. Creasy, Amy Chen, Konstantinos Liolios, Ken Chu, Noam J. Davidovics, Mark J. Mazaitis, Todd Z. DeSantis, Navjeet Singh, Joshua Orvis, Jonathan Crabtree, Victor Felix, Catherine Jordan, Anup Mahurkar, Rob Knight, Gary L. Andersen, Nikos C. Kyrpides, Victor Markowitz, Owen White   +19 more
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Ethical, legal, and social considerations in conducting the Human Microbiome Project [PDF]

Genome Research, 2008
The early days of the genomic revolution—from the Asilomar Conference on Recombinant DNA in 1975 to the founding of the Human Genome Project in 1990—were marked by awareness among researchers, government officials, and policy makers that emerging scientific knowledge raised a host of ethical, legal, and social challenges.
Amy L. McGuire, James Colgrove, Simon N. Whitney, Christina M. Diaz, Daniel Bustillos, James Versalovic   +5 more
openalex   +5 more sources

NIH Builds Substantial Human Microbiome Project [PDF]

Microbe Magazine, 2009
The human genome proved surprisingly skimpy, encoding somewhere in the range of a mere 20,000 proteins, on the same order as the fruit fly genome—a psychologically humbling number. However, humans provide a scaffold upon which microbes build elaborate ecosystems and, by young adulthood, each of us carries many more microbial genes than our own.
Marcia Stone
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HMP16SData: Efficient Access to the Human Microbiome Project through Bioconductor [PDF]

American Journal of Epidemiology, 2018
AbstractPhase 1 of the NIH Human Microbiome Project (HMP) investigated 18 body subsites of 239 healthy American adults, to produce the first comprehensive reference for the composition and variation of the “healthy” human microbiome. Publicly-available data sets from amplicon sequencing of two 16S rRNA variable regions, with extensive controlled-access
Lucas Schiffer, Rimsha Azhar, Lori Shepherd, Marcel Ramos, Ludwig Geistlinger, Curtis Huttenhower, Jennifer B. Dowd, Nicola Segata, Levi Waldron   +8 more
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Microbial community profiling for human microbiome projects: Tools, techniques, and challenges [PDF]

Genome Research, 2009
High-throughput sequencing studies and new software tools are revolutionizing microbial community analyses, yet the variety of experimental and computational methods can be daunting. In this review, we discuss some of the different approaches to community profiling, highlighting strengths and weaknesses of various experimental approaches, sequencing ...
Micah Hamady, Rob Knight
openalex   +5 more sources

Human oral microbiome characterization and its association with environmental microbiome revealed by the Earth Microbiome Project [PDF]

, 2019
AbstractThe oral cavity is an important window for the microbial communication between environment and the human body. The oral microbiome plays an important role in human health. Here, we analyzed 447 datasets from human oral samples published by the Earth Microbiome Project (EMP).
Jinlan Wang, Dandan Li, Jianing Wang, Zheng Zhang   +3 more
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The Urinary Microbiome: A Pediatric Urological Perspective [PDF]

Urogenital Tract Infection, 2022
The human microbiome is currently being studied with increasing interest. The microbiome refers to the microorganisms living in the body and their genetic information.
Sang Don Lee, Jae Min Chung
doaj   +1 more source