Results 31 to 40 of about 56,721 (97)

Role of the microbiome, probiotics, and 'dysbiosis therapy' in critical illness. [PDF]

, 2016
Purpose of reviewLoss of 'health-promoting' microbes and overgrowth of pathogenic bacteria (dysbiosis) in ICU is believed to contribute to nosocomial infections, sepsis, and organ failure (multiple organ dysfunction syndrome).
Knight, Rob, McDonald, Daniel, Wischmeyer, Paul E   +2 more
core   +2 more sources

Extreme Dysbiosis of the Microbiome in Critical Illness. [PDF]

, 2016
Critical illness is hypothesized to associate with loss of "health-promoting" commensal microbes and overgrowth of pathogenic bacteria (dysbiosis). This dysbiosis is believed to increase susceptibility to nosocomial infections, sepsis, and organ failure.
Christine Baird, Christine Vis-Kampen, Daniel McDonald, Daren Heyland, Gail Ackermann, Judy King, Karrie Derenski, Ludmila Khailova, Margot Lemieux, Paul E. Wischmeyer, Rob Knight, Rosemary Kozar, Susannah Green Tringe   +12 more
core   +2 more sources

Ethical, legal, and social considerations in conducting the Human Microbiome Project [PDF]

Genome Research, 2008
The early days of the genomic revolution—from the Asilomar Conference on Recombinant DNA in 1975 to the founding of the Human Genome Project in 1990—were marked by awareness among researchers, government officials, and policy makers that emerging scientific knowledge raised a host of ethical, legal, and social challenges.
Christina M. Diaz, Simon N. Whitney, Daniel Bustillos, James Colgrove, James Versalovic, Amy L. McGuire   +5 more
openaire   +3 more sources

The Computational Diet: A Review of Computational Methods Across Diet, Microbiome, and Health. [PDF]

, 2020
Food and human health are inextricably linked. As such, revolutionary impacts on health have been derived from advances in the production and distribution of food relating to food safety and fortification with micronutrients. During the past two decades,
Eetemadi, Ameen, Kim, Minseung, Pereira, Beatriz Merchel Piovesan, Rai, Navneet, Schmitz, Harold, Tagkopoulos, Ilias   +5 more
core  

Tiny microbes, enormous impacts: what matters in gut microbiome studies? [PDF]

, 2016
Many factors affect the microbiomes of humans, mice, and other mammals, but substantial challenges remain in determining which of these factors are of practical importance. Considering the relative effect sizes of both biological and technical covariates
Debelius, Justine, Gonzalez, Antonio, Knight, Rob, Song, Se Jin, Vazquez-Baeza, Yoshiki, Xu, Zhenjiang Zech   +5 more
core   +1 more source

Advancing the Microbiome Research Community [PDF]

, 2014
The human microbiome has become a recognized factor in promoting and maintaining health. We outline opportunities in interdisciplinary research, analytical rigor, standardization, and policy development for this relatively new and rapidly developing ...
Brown, C. Titus, Caporaso, J. Gregory, Clemente, Jose C., Franzosa, Eric A., Gevers, Dirk, Huttenhower, Curtis, Izard, Jacques, Kelley, Scott T., Knight, Rob, Knights, Dan, Ley, Ruth E., Mahurkar, Anup, Ravel, Jacques, The Scientists for Advancement of Microbiome Research, White, Owen   +14 more
core   +2 more sources

The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information [PDF]

, 2010
The human oral microbiome is the most studied human microflora, but 53% of the species have not yet been validly named and 35% remain uncultivated. The uncultivated taxa are known primarily from 16S rRNA sequence information.
Baranova, Oxana V., Chen, Tsute, Dewhirst, Floyd E., Izard, Jacques, Lakshmanan, Abirami, Yu, Wen-Han   +5 more
core   +1 more source

The Human Microbiome Project: An Opportunity to Engage Undergraduates in Research

Procedia Computer Science, 2012
AbstractThe Human Microbiome Project (HMP) aims to characterize the diversity of microbial species found at several different sites on the human body. The HMP has sequenced hundreds of microbial reference genomes from multiple body sites and provides a wealth of primary genomic sequence data for analysis.
Ramana Madupu, Gaurav Arora, Anne G. Rosenwald, Janet S. Russell, Jennifer Roecklein-Canfield   +4 more
openaire   +2 more sources

HMPDACC: a Human Microbiome Project Multi-omic data resource

Nucleic Acids Research, 2020
Abstract The Human Microbiome Project (HMP) explored microbial communities of the human body in both healthy and disease states. Two phases of the HMP (HMP and iHMP) together generated >48TB of data (public and controlled access) from multiple, varied omics studies of both the microbiome and associated hosts.
Heather Huot Creasy, Victor Felix, Jain Aluvathingal, Jonathan Crabtree, Olukemi Ifeonu, James Matsumura, Carrie McCracken, Lance Nickel, Joshua Orvis, Mike Schor, Michelle Giglio, Anup Mahurkar, Owen White   +12 more
openaire   +3 more sources

Microbial community profiling for human microbiome projects: Tools, techniques, and challenges [PDF]

Genome Research, 2009
High-throughput sequencing studies and new software tools are revolutionizing microbial community analyses, yet the variety of experimental and computational methods can be daunting. In this review, we discuss some of the different approaches to community profiling, highlighting strengths and weaknesses of various experimental approaches, sequencing ...
Micah Hamady, Rob Knight
openaire   +3 more sources