Results 81 to 90 of about 1,243,598 (300)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Modulating the developing gut microbiota with 2’-fucosyllactose and pooled human milk oligosaccharides

Microbiome
Background Synthetic human milk oligosaccharides (HMOs) are used to supplement infant formula despite limited understanding of their impact on the post-weaned developing gut microbiota. Here, we assess the influence of 0.5 g/L 2-fucosyllactose (2’FL) and
Simone Renwick, Annalee Furst, Mikael Knip, on behalf of the DIABIMMUNE Study Group, Lars Bode, Jayne S. Danska, Emma Allen-Vercoe   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Diversity of Human Milk Oligosaccharides and Effects on Early Life Immune Development

Frontiers in Pediatrics, 2018
One of the well-known features of human milk, is the capacity to protect against the risk and impact of neonatal infections, as well as to influence the onset of allergic and metabolic disease manifestations.
Veronica Ayechu-Muruzabal, Arthur H. van Stigt, Marko Mank, Linette E. M. Willemsen, Bernd Stahl, Johan Garssen, Johan Garssen, Belinda van't Land, Belinda van't Land   +8 more
doaj   +1 more source

PCR Based Genotyping of Lulu Cattle of Nepal for A1, A2 Type Beta-caseins [PDF]

, 2020
Lulu is an indigenous breed of cattle (Bos taurus) found in high altitude regions of western Nepal. Population of Lulu cattle has been declining due to introgression with other exotic breeds to increase milk productivity.
Budhathoki, N. (Nabina), GC, S. (Sudarshan), Gorkhali, N. A. (Neena), Lama, S. (Srijana), Pokharel, P. (Prashanna), Pokhrel, B. R. (Bhoj), Sapkota, S. (Saroj), Sherpa, C. (Chhiring)   +7 more
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Donation barriers, enablers, patterns and predictors of milk bank donors in the United States and United Kingdom

Maternal and Child Nutrition
Pasteurised donor human milk is recommended for very low birthweight infants who do not have access to their mother's milk. Although the use of donor milk continues to increase, little is known about the donation experiences of milk bank donors. We aimed
Bruna Gutierrez dosSantos, Natalie Shenker, Gillian Weaver, Maryanne T. Perrin   +3 more
doaj   +1 more source

Research Progress of Sensors Technology Based on DNA Walker in Food Safety Detection

Shipin gongye ke-ji
With the rapid development of DNA nanotechnology, DNA molecules with various structures and functions are used to construct programmable nanomachines with dynamic behaviors.
Siqing SONG, Xiaoxia SI, Jufeng HU, Zimo DU, Lijun CHEN, Jichao LIU   +5 more
doaj   +1 more source