Results 51 to 60 of about 1,532,021 (269)

Effect of Fatiguing Wheelchair Propulsion and Weight Relief Lifts on Subacromial Space in Wheelchair Users

Frontiers in Rehabilitation Sciences, 2022
ObjectiveThis study aimed to identify targets of intervention for reducing shoulder pain in wheelchair users with spinal cord injury (SCI) by (1) examining changes in subacromial space [acromiohumeral distance (AHD) and occupation ratio (OccRatio)] with ...
Ursina Arnet, Michael L. Boninger, Ann Cools, Fransiska M. Bossuyt, Fransiska M. Bossuyt   +4 more
doaj   +1 more source

Predicting commuter flows in spatial networks using a radiation model based on temporal ranges

, 2014
Understanding network flows such as commuter traffic in large transportation networks is an ongoing challenge due to the complex nature of the transportation infrastructure and of human mobility.
Ercsey-Ravasz, Mária, González, Marta C., Ren, Yihui, Toroczkai, Zoltán, Wang, Pu   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Customer mobility and congestion in supermarkets

, 2019
The analysis and characterization of human mobility using population-level mobility models is important for numerous applications, ranging from the estimation of commuter flows in cities to modeling trade flows between countries.
Beguerisse-Díaz, Mariano, Howison, Sam D., Porter, Mason A., Wallis, Alisdair O. G., Ying, Fabian   +4 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Phase transitions in contagion processes mediated by recurrent mobility patterns [PDF]

, 2011
Human mobility and activity patterns mediate contagion on many levels, including the spatial spread of infectious diseases, diffusion of rumors, and emergence of consensus.
A Barrat, A Barrat, A Rapoport, A Vázquez, AL Lloyd, AL Lloyd, Alessandro Vespignani, AN Tabah, BM Bolker, BM Bolker, C Song, C Song, D Balcan, D Balcan, D Brockmann, D Watts, DJ Daley, Duygu Balcan, F Ball, G Chowell, J Marro, K Dietz, L Hufnagel, L Sattenspiel, LA Rvachev, M Barthélemy, M Catanzaro, M Molloy, MC González, MJ Keeling, MJ Keeling, NG van Kampen, NT Bailey, P Cross, P Cross, P Wang, R Cohen, R Guimerá, R Pastor-Satorras, R Patuelli, RF Grais, RM May, S Ni, TE Harris, V Colizza, V Colizza, V Colizza, V Colizza, W Goffman, W Goffman, Y Ben-Zion   +50 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Matchmaker, Matchmaker, Make Me a Match: Migration of Populations via Marriages in the Past

, 2014
The study of human mobility is both of fundamental importance and of great potential value. For example, it can be leveraged to facilitate efficient city planning and improve prevention strategies when faced with epidemics.
Abrams, Daniel M., Ffrancon, Robyn, Kim, Beom Jun, Lee, Sang Hoon, Porter, Mason A.   +4 more
core   +2 more sources

Human mobility monitoring in very low resolution visual sensor network [PDF]

, 2014
This paper proposes an automated system for monitoring mobility patterns using a network of very low resolution visual sensors (30 30 pixels). The use of very low resolution sensors reduces privacy concern, cost, computation requirement and power ...
Aghajan, Hamid, Deboeverie, Francis, Eldib, Mohamed, Guan, Junzhi, Kleihorst, Richard, Niño Castañeda, Jorge, Nyan, Bo Bo, Philips, Wilfried, Slembrouck, Maarten, Steendam, Heidi, Van de Velde, Samuel, Van Haerenborgh, Dirk, Veelaert, Peter, Xie, Xingzhe   +13 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source