Results 71 to 80 of about 118,196 (306)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Automated markerless analysis of human gait motion for recognition and classification

open access: yes, 2011
We present a new method for an automated markerless system to describe, analyze, and classify human gait motion. The automated system consists of three stages: i) detection and extraction of the moving human body and its contour from image sequences, ii)
yoo, jang hee   +3 more
core   +1 more source

Constructing Human Motion Manifold With Sequential Networks

open access: yes, 2020
This paper presents a novel recurrent neural network‐based method to construct a latent motion manifold that can represent a wide range of human motions in a long sequence. We introduce several new components to increase the spatial and temporal coverage
Lee, Sung‐Hee, Jang, Deok‐Kyeong
core   +1 more source

When are abrupt onsets found efficiently in complex visual search? : evidence from multi-element asynchronous dynamic search [PDF]

open access: yes, 2014
Previous work has found that search principles derived from simple visual search tasks do not necessarily apply to more complex search tasks. Using a Multielement Asynchronous Dynamic (MAD) visual search task, in which high numbers of stimuli could ...
Watson, Derrick G., Kunar, Melina A.
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Automated Markerless Extraction of Walking People Using Deformable Contour Models

open access: yes, 2004
We develop a new automated markerless motion capture system for the analysis of walking people. We employ global evidence gathering techniques guided by biomechanical analysis to robustly extract articulated motion.
Mark S. Nixon   +3 more
core   +1 more source

Enhancing silhouette-based human motion capture with 3D motion fields [PDF]

open access: yes11th Pacific Conference onComputer Graphics and Applications, 2003. Proceedings., 2004
High-quality nonintrusive human motion capture is necessary for acquisition of model-based free-viewpoint video of human actors. Silhouette-based approaches have demonstrated that they are able to accurately recover a large range of human motion from multiview video.
Christian Theobalt   +3 more
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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