Results 81 to 90 of about 9,503,439 (290)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Calibrationless monocular vision musculoskeletal simulation during gait

Heliyon
With computer vision technology and prediction of ground reaction forces (GRF), a previous study performed markerless motion capture and musculoskeletal simulation with two smartphones (OpenCap).
Ryo Ueno
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Human joint motion data capture and fusion based on wearable sensors

Autonomous Intelligent Systems
The field of human motion data capture and fusion has a broad range of potential applications and market opportunities. The capture of human motion data for wearable sensors is less costly and more convenient than other methods, but it also suffers from ...
Hua Wang
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Automated Markerless Extraction of Walking People Using Deformable Contour Models

, 2004
We develop a new automated markerless motion capture system for the analysis of walking people. We employ global evidence gathering techniques guided by biomechanical analysis to robustly extract articulated motion.
Mark S. Nixon, Nixon, Mark S, Wagg, David K, David K. Wagg   +3 more
core   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Recognizing Human Motion Using Eigensequences [PDF]

, 2007
This paper presents a novel method for motion recognition. The approach is based on 3D motion data. The captured motion is divided into sequences, which are sets of contiguous postures over time.
Bottino, Andrea Giuseppe, Laurentini, Aldo, De Simone, Matteo, Bottino, Andrea   +3 more
core  

VisMocap: Interactive visualization and analysis for multi-source motion capture data

Visual Informatics
With the rapid advancement of artificial intelligence, research on enabling computers to assist humans in achieving intelligent augmentation—thereby enhancing the accuracy and efficiency of information perception and processing—has been steadily evolving.
Lishuang Zhan, Rongting Li, Rui Cao, Juncong Lin, Shihui Guo   +4 more
doaj   +1 more source