Results 111 to 120 of about 8,048,182 (359)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Foreigners to human nature [PDF]
Annales Scientia Politica, 2019 Is there a relation between wealth and human nature? Can the Delphic maxim "know thyself” (γνῶθι σεαυτὸν) help us decide whether or not to be affluent and wealthy? And if so: how rich? Human beings, says Aristotle, can only use and benefit from a limited
Carlos McCadden
doaj
Narratives to revert overconsumption: human-nature interdependence and Circular Economy. [PDF]
Agric Food Econ, 2023 Borrello M, Cembalo L, D'Amico V.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The Essence of Hindu Doctrine and its Influence on Christianity in America and Europe [PDF]
International Journal of Orthodox Theology, 2015 This paper addresses the topic of the identity of Hindu religion and its impact on Christianity in the West (i.e. in Europe and USA), which is to be seen, especially through Neo-Hindu movements (that occurred mainly during 1950s–1980s).
Alexandru-Corneliu Arion
doaj
Does socioeconomic position and gender affect human-nature interactions? [PDF]
J Public Health (Berl), 2022 Tiscareno-Osorno X +6 more
europepmc +1 more source
, 2023 Human nature is frequently evoked to characterize our species and describe how it differs from others. But how should we understand this concept? What is the nature of a species? Some take our nature to be an essence and argue that because humans lack an essence, they also lack a nature.
openaire +1 more source