Results 141 to 150 of about 8,092,812 (313)

Predicting commuter flows in spatial networks using a radiation model based on temporal ranges

, 2014
Understanding network flows such as commuter traffic in large transportation networks is an ongoing challenge due to the complex nature of the transportation infrastructure and of human mobility.
Ercsey-Ravasz, Mária, González, Marta C., Ren, Yihui, Toroczkai, Zoltán, Wang, Pu   +4 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Editorial: Imaginative culture and human nature: Evolutionary perspectives on the arts, religion, and ideology. [PDF]

Front Psychol, 2022
Carroll J, Johnson JA, Jonsson E, Jung RE, van Mulukom V.   +4 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Art and human nature

Avances en Psicología Latinoamericana, 2009
Este artículo presenta un punto de vista sobre el trabajo del artista de lo visual, que confronta el canon tradicional eurocéntrico con algunas tradiciones, ignoradas pero valiosas, proponiendo así un contracanon.
Mirta Toledo
doaj  

Rereading Habermas in Times of CRISPR-cas: A Critique of and an Alternative to the Instrumentalist Interpretation of the Human Nature Argument. [PDF]

J Bioeth Inq, 2022
Wienmeister A.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Nature of Human Rights

Revista Latinoamericana de Derechos Humanos, 2016
In the formation of a new Constitution the constituents will require to know or reach an agreement on the nature of human rights; then, to determine how the State will enforce the respect to those rights.
Carlos López Dawson
doaj  

Impact of the COVID-19 pandemic on human-nature relations in a remote nature-based tourism destination. [PDF]

PLoS One, 2022
Mul E, Ancin Murguzur FJ, Hausner VH.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source