Results 1 to 10 of about 38,742 (265)

25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids [PDF]

Journal of Virology
Norovirus is the leading cause of acute gastroenteritis worldwide. Since the development of human intestinal enteroid (HIE) cell culture systems, significant advancements have been made in exploring and evaluating therapeutic strategies to combat human ...
Verónica Costantini, Wadzanai P. Mboko, Helen Wall, Kimberly Huynh, Anna M. Montmayeur, Geun Woo Park, Ruijie Xu, Jan Vinjé, Preeti Chhabra   +8 more
doaj   +2 more sources

Human norovirus in Brazil: an update of reports in different settings. [PDF]

Braz J Microbiol
Oliveira JGDS, Costa ASDS, Ferreira IV, Carvalho MO, Siqueira JAM, Aires CAM.   +5 more
europepmc   +3 more sources

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories. [PDF]

Sci Adv
Kaundal S, Anish R, Ayyar BV, Shanker S, Kaur G, Crawford SE, Pollet J, Stossi F, Estes MK, Prasad BVV.   +9 more
europepmc   +2 more sources

Use of Human Intestinal Enteroids to Evaluate Persistence of Infectious Human Norovirus in Seawater

Emerging Infectious Diseases, 2022
Little data on the persistence of human norovirus infectivity are available to predict its transmissibility. Using human intestinal enteroids, we demonstrate that 2 human norovirus strains can remain infectious for several weeks in seawater.
Marion Desdouits, David Polo, Cecile Le Mennec, Sofia Strubbia, Xi-Lei Zeng, Khalil Ettayebi, Robert L. Atmar, Mary K. Estes, Françoise S. Le Guyader   +8 more
doaj   +1 more source

Unraveling the interplay between norovirus infection, gut microbiota, and novel antiviral approaches: a comprehensive review

Frontiers in Microbiology, 2023
Norovirus infection is a leading cause of acute gastroenteritis worldwide and can also cause harmful chronic infections in individuals with weakened immune systems.
Geng-Hao Bai, Meng-Chen Tsai, Sheng-Chieh Lin, Sheng-Chieh Lin, Yi-Hsiang Hsu, Yi-Hsiang Hsu, Shih-Yen Chen, Shih-Yen Chen, Shih-Yen Chen   +8 more
doaj   +1 more source

Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China

Open Life Sciences, 2022
Norovirus is a prominent enteric virus responsible for severe acute gastroenteritis disease burden worldwide. In our current study, we analyzed 7,804 norovirus sequences of human and animals in China which were detected from 1980 to 2020 from GenBank ...
Li Manyu, Li Kejian, Lan Haiyun, Hao Xiaotian, Liu Yan, Zhou Cheng   +5 more
doaj   +1 more source

Illuminating Human Norovirus: A Perspective on Disinfection of Water and Surfaces Using UVC, Norovirus Model Organisms, and Radiation Safety Considerations

Pathogens, 2022
Human noroviruses (HuNoVs) are a major cause of gastroenteritis and are associated with high morbidity because of their ability to survive in the environment and small inoculum size required for infection.
Richard M. Mariita, James H. Davis, Rajul V. Randive   +2 more
doaj   +1 more source

Nonstructural protein 4 of human norovirus self-assembles into various membrane-bridging multimers. [PDF]

J Biol Chem
Royet A, Ruedas R, Gargowitsch L, Gervais V, Habersetzer J, Pieri L, Ouldali M, Paternostre M, Hofmann I, Tubiana T, Fieulaine S, Bressanelli S.   +11 more
europepmc   +3 more sources

Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples

Emerging Infectious Diseases, 2021
A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported.
Marie Hagbom, Jenny Lin, Tina Falkeborn, Lena Serrander, Jan Albert, Johan Nordgren, Sumit Sharma   +6 more
doaj   +1 more source

Human Intestinal Enteroids to Evaluate Human Norovirus GII.4 Inactivation by Aged-Green Tea

Frontiers in Microbiology, 2020
Human noroviruses are the leading cause of epidemic and sporadic acute gastroenteritis worldwide and the most common cause of foodborne illness in the United States.
Walter Randazzo, Walter Randazzo, Veronica Costantini, Esther K. Morantz, Esther K. Morantz, Jan Vinjé   +5 more
doaj   +1 more source