VPg of murine norovirus binds translation initiation factors in infected cells [PDF]
Virology Journal, 2006 Background Norovirus genomic and subgenomic RNAs are covalently linked at the 5' nucleotide to a 15 kD protein called VPg. VPg of two human norovirus strains binds translation initiation factor eIF3 and other eIFs in vitro, suggesting VPg functions in ...
Wobus Christiane E +2 more
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Human Norovirus Infection in Dogs, Thailand [PDF]
Emerging Infectious Diseases, 2020 In July 2018, recombinant norovirus GII.Pe-GII.4 Sydney was detected in dogs who had diarrhea in a kennel and in children living on the same premises in Thailand.
Kamonpan Charoenkul +10 more
doaj +3 more sources
Animals as Reservoir for Human Norovirus [PDF]
Viruses, 2019 Norovirus is the most common cause of non-bacterial gastroenteritis and is a burden worldwide. The increasing norovirus diversity is currently categorized into at least 10 genogroups which are further classified into more than 40 genotypes.
Nele Villabruna +2 more
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Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2 [PDF]
mBio, 2017 The Norovirus genus contains important human pathogens, but the role of host pathways in norovirus replication is largely unknown. Murine noroviruses provide the opportunity to study norovirus replication in cell culture and in small animals.
Broc T. McCune +10 more
doaj +5 more sources
Effect of food residues on norovirus survival on stainless steel surfaces. [PDF]
PLoS ONE, 2011 BACKGROUND: In households and food processing plants, minute food residues left behind from improper cleaning may influence the survivability of human norovirus on surfaces.
Hajime Takahashi +4 more
doaj +6 more sources
Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation [PDF]
eLife, 2019 Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a CRISPR screen,
Myra Hosmillo +14 more
doaj +5 more sources
Fucose Binding Cancels out Mechanical Differences between Distinct Human Noroviruses [PDF]
Viruses, 2023 The majority of nonbacterial gastroenteritis in humans and livestock is caused by noroviruses. Like most RNA viruses, frequent mutations result in various norovirus variants.
Yuzhen Feng +5 more
doaj +3 more sources
A model for estimating pathogen variability in shellfish and predicting minimum depuration times. [PDF]
PLoS ONE, 2018 Norovirus is a major cause of viral gastroenteritis, with shellfish consumption being identified as one potential norovirus entry point into the human population.
Paul McMenemy +4 more
doaj +6 more sources
Advances in Human Norovirus Vaccine Research [PDF]
Vaccines, 2021 Human norovirus (HuNoV) is the leading cause of acute gastroenteritis (AGE) worldwide, which is highly stable and contagious, with a few virus particles being sufficient to establish infection. Although the World Health Organization in 2016 stated that it should be an absolute priority to develop a HuNoV vaccine, unfortunately, there is currently no ...
Mudan Zhang, Ming Fu, Qinxue Hu
openaire +5 more sources
Glycan Recognition in Human Norovirus Infections [PDF]
Viruses, 2021 Recognition of cell-surface glycans is an important step in the attachment of several viruses to susceptible host cells. The molecular basis of glycan interactions and their functional consequences are well studied for human norovirus (HuNoV), an important gastrointestinal pathogen.
Victoria R. Tenge +6 more
openaire +4 more sources