Results 11 to 20 of about 38,742 (265)

Human Norovirus Infection in Dogs, Thailand [PDF]

Emerging Infectious Diseases, 2020
In July 2018, recombinant norovirus GII.Pe-GII.4 Sydney was detected in dogs who had diarrhea in a kennel and in children living on the same premises in Thailand.
Kamonpan Charoenkul, Chanakarn Nasamran, Taveesak Janetanakit, Ratanaporn Tangwangvivat, Napawan Bunpapong, Supanat Boonyapisitsopa, Kamol Suwannakarn, Apiradee Theamboonler, Watchaporn Chuchaona, Yong Poovorawan, Alongkorn Amonsin   +10 more
doaj   +3 more sources

Animals as Reservoir for Human Norovirus [PDF]

Viruses, 2019
Norovirus is the most common cause of non-bacterial gastroenteritis and is a burden worldwide. The increasing norovirus diversity is currently categorized into at least 10 genogroups which are further classified into more than 40 genotypes.
Nele Villabruna, Marion P. G. Koopmans, Miranda de Graaf   +2 more
doaj   +4 more sources

Human norovirus inhibition by a human milk oligosaccharide

Virology, 2017
Human noroviruses are the leading cause of outbreaks of acute gastroenteritis. Norovirus interactions with histo-blood group antigens (HBGAs) are known to be important for an infection. In this study, we identified the HBGA binding pocket for an emerging GII genotype 17 (GII.17) variant using X-ray crystallography.
A.D. Koromyslova, Shailesh Tripathi, Vasily Morozov, Horst Schroten, Grant S. Hansman   +4 more
openalex   +5 more sources

Use of Human Intestinal Enteroids to Detect 
Human Norovirus Infectivity [PDF]

Emerging Infectious Diseases, 2019
Tools to detect human norovirus infectivity have been lacking. Using human intestinal enteroid cultures inoculated with GII.Pe-GII.4 Sydney–infected fecal samples, we determined that a real-time reverse transcription PCR cycle threshold cutoff of 30 may ...
Martin Chi-Wai Chan, Sarah K.C. Cheung, Kirran N. Mohammad, Jenny C.M. Chan, Mary K. Estes, Paul K.S. Chan   +5 more
doaj   +3 more sources

Human Norovirus Molecular Analysis and Development of Norovirus Vaccine

Indonesian Journal of Tropical and Infectious Disease, 2022
The most common organism of acute viral gastroenteritis is norovirus, which accounts for roughly 20% of all occurrences of acute gastroenteritis globally. The virus kills over 200,000 children each year and is the leading cause of childhood diarrhea in the rotavirus-vaccinated population.
Adinda Juwita Syakila Elizafanti, Maria Inge Lusida, Muhammad Miftahussurur, Alpha Fardah Athiyyah   +3 more
openalex   +5 more sources

Glycan Recognition in Human Norovirus Infections [PDF]

Viruses, 2021
Recognition of cell-surface glycans is an important step in the attachment of several viruses to susceptible host cells. The molecular basis of glycan interactions and their functional consequences are well studied for human norovirus (HuNoV), an important gastrointestinal pathogen.
Victoria R. Tenge, Liya Hu, B. V. Venkataram Prasad, Göran Larson, Robert L. Atmar, Mary K. Estes, Sasirekha Ramani   +6 more
openaire   +3 more sources

Advances in Human Norovirus Vaccine Research [PDF]

Vaccines, 2021
Human norovirus (HuNoV) is the leading cause of acute gastroenteritis (AGE) worldwide, which is highly stable and contagious, with a few virus particles being sufficient to establish infection. Although the World Health Organization in 2016 stated that it should be an absolute priority to develop a HuNoV vaccine, unfortunately, there is currently no ...
Mudan Zhang, Ming Fu, Qinxue Hu
openaire   +4 more sources

Dasabuvir inhibits human norovirus infection in human intestinal enteroids [PDF]

mSphere, 2021
AbstractHuman noroviruses (HuNoVs) are acute viral gastroenteritis pathogens that affect all age groups, yet no approved vaccines and drugs to treat HuNoV infection are available. In this study, with a human intestinal enteroid (HIE) culture system where HuNoVs are able to replicate reproducibly, we screened an antiviral compound library to identify ...
Tsuyoshi Hayashi, Kosuke Murakami, Junki Hirano, Yoshiki Fujii, Yoko Yamaoka, Hirofumi Ohashi, Koichi Watashi, Mary K. Estes, Masamichi Muramatsu   +8 more
openaire   +3 more sources

2'-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids. [PDF]

J Virol
ABSTRACTHuman noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment factors for HuNoVs; molecules that block the binding of HuNoVs to HBGAs thus have the ...
Patil K, Ayyar BV, Hayes NM, Neill FH, Bode L, Estes MK, Atmar RL, Ramani S.   +7 more
europepmc   +5 more sources

Exosome-mediated human norovirus infection

PLOS ONE, 2020
Human norovirus (HuNoV) is a leading cause of acute gastroenteritis. Outbreaks normally occur via the fecal-oral route. HuNoV infection is thought to occur by viral particle transmission, but increasing evidence suggests a function for exosomes in HuNoV infection.
Kyle V. Todd, Ralph A. Tripp
openaire   +4 more sources