Results 21 to 30 of about 103,711 (181)
CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus
PLOS Pathogens, 2020 Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major determinant of cell tropism, host range, and pathogenesis. The bona fide receptor for HNoV is unknown. Recently, we identified CD300lf as a proteinaceous receptor for MNoV.
Vincent R. Graziano +17 more
openaire +8 more sources
A Mouse Model for Human Norovirus [PDF]
mBio, 2013 ABSTRACT Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since “humanized” mice have been successfully used to study human-tropic pathogens in the past, we challenged BALB/c mice deficient in ...
Taube, Stefan +8 more
openaire +5 more sources
In Vitro Replication of Human Norovirus [PDF]
Viruses, 2019 Human norovirus (HuNoV) infection is a major cause of gastroenteritis all over the world. Despite this, these non-enveloped RNA viruses are poorly characterized due to the lack of robust and widely available HuNoV culture systems. The two published systems (B cell line and stem cell-derived enteroids) support replication of HuNoVs but the levels of ...
Melissa K. Jones, Sutonuka Bhar
openaire +4 more sources
Human Norovirus Molecular Analysis and Development of Norovirus Vaccine
Indonesian Journal of Tropical and Infectious Disease, 2022 The most common organism of acute viral gastroenteritis is norovirus, which accounts for roughly 20% of all occurrences of acute gastroenteritis globally. The virus kills over 200,000 children each year and is the leading cause of childhood diarrhea in the rotavirus-vaccinated population.
Adinda Juwita Syakila Elizafanti, - +3 more
openaire +3 more sources
Human Norovirus: Experimental Models of Infection [PDF]
Viruses, 2019 Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. A lack of well-characterized in vitro and in vivo infection models has limited the development of HuNoV
Kyle V. Todd, Ralph A. Tripp
openaire +3 more sources
Heat-Denatured Lysozyme Inactivates Murine Norovirus as a Surrogate Human Norovirus [PDF]
Scientific Reports, 2015 AbstractHuman norovirus infects humans through the consumption of contaminated food, contact with the excrement or vomit of an infected person and through airborne droplets that scatter the virus through the air. Being highly infectious and highly viable in the environment, inactivation of the norovirus requires a highly effective inactivating agent ...
Miki Sato +8 more
openaire +2 more sources
Exosome-mediated human norovirus infection
PLOS ONE, 2020 Human norovirus (HuNoV) is a leading cause of acute gastroenteritis. Outbreaks normally occur via the fecal-oral route. HuNoV infection is thought to occur by viral particle transmission, but increasing evidence suggests a function for exosomes in HuNoV infection.
Kyle V. Todd, Ralph A. Tripp
openaire +5 more sources
Norovirus Infectivity in Humans and Persistence in Water [PDF]
Applied and Environmental Microbiology, 2011 ABSTRACT To examine the long-term infectivity of human norovirus in water, 13 study subjects were challenged at different time points with groundwater spiked with the prototype human norovirus, Norwalk virus. Norwalk virus spiked in groundwater remained infectious after storage at room temperature in the dark for 61 days (the ...
Melissa Dowd +11 more
openaire +3 more sources
Viruses, 2019 Human norovirus is the major cause of non-bacterial epidemic gastroenteritis. Human norovirus binds to environmental solids via specific and non-specific interactions, and several specific receptors for human norovirus have been reported.
Mohan Amarasiri, Daisuke Sano
doaj +1 more source
Characterizing spreading dynamics of subsampled systems with non-stationary external input [PDF]
Phys. Rev. E 102, 040301 (2020), 2020 Many systems with propagation dynamics, such as spike propagation in neural networks and spreading of infectious diseases, can be approximated by autoregressive models. The estimation of model parameters can be complicated by the experimental limitation that one observes only a fraction of the system (subsampling) and potentially time-dependent ...
arxiv +1 more source