Human Norovirus: Experimental Models of Infection [PDF]
Viruses, 2019 Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. A lack of well-characterized in vitro and in vivo infection models has limited the development of HuNoV
Kyle V. Todd, Ralph A. Tripp
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VPg of murine norovirus binds translation initiation factors in infected cells
Virology Journal, 2006 Background Norovirus genomic and subgenomic RNAs are covalently linked at the 5' nucleotide to a 15 kD protein called VPg. VPg of two human norovirus strains binds translation initiation factor eIF3 and other eIFs in vitro, suggesting VPg functions in ...
Wobus Christiane E +2 more
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Comparing Human Norovirus Surrogates: Murine Norovirus and Tulane Virus
Journal of Food Protection, 2013 Viral surrogates are widely used by researchers to predict human norovirus behavior. Murine norovirus (MNV) is currently accepted as the best surrogate and is assumed to mimic the survival and inactivation of human noroviruses. Recently, a new calicivirus, the Tulane virus (TV), was discovered, and its potential as a human norovirus surrogate is being
Kirsten A, Hirneisen, Kalmia E, Kniel
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Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures [PDF]
, 2017 Vesivirus 2117 is an adventitious agent that in 2009, was identified as a contaminant of CHO cells propagated in bioreactors at a pharmaceutical manufacturing plant belonging to Genzyme.
Bhella, David +8 more
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Norovirus Attachment and Entry
Viruses, 2019 Human norovirus is a major human pathogen causing the majority of cases of viral gastroenteritis globally. Viral entry is the first step of the viral life cycle and is a significant determinant of cell tropism, host range, immune interactions, and ...
Vincent R. Graziano +2 more
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Heat-Denatured Lysozyme Inactivates Murine Norovirus as a Surrogate Human Norovirus [PDF]
Scientific Reports, 2015 AbstractHuman norovirus infects humans through the consumption of contaminated food, contact with the excrement or vomit of an infected person and through airborne droplets that scatter the virus through the air. Being highly infectious and highly viable in the environment, inactivation of the norovirus requires a highly effective inactivating agent ...
Hajime Takahashi +8 more
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New proof-of-concept in viral inactivation: virucidal efficacy of 405 nm light against feline calicivirus as a model for norovirus decontamination [PDF]
, 2016 The requirement for novel decontamination technologies for use in hospitals is ever present. One such system uses 405 nm visible light to inactivate microorganisms via ROS-generated oxidative damage.
Anderson, John G. +7 more
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Effect of food residues on norovirus survival on stainless steel surfaces. [PDF]
PLoS ONE, 2011 BACKGROUND: In households and food processing plants, minute food residues left behind from improper cleaning may influence the survivability of human norovirus on surfaces.
Hajime Takahashi +4 more
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Targeted Profiling of Immunological Genes during Norovirus Replication in Human Intestinal Enteroids
Viruses, 2021 Norovirus is the leading cause of acute gastroenteritis worldwide. The pathogenesis of norovirus and the induced immune response remain poorly understood due to the lack of a robust virus culture system.
Jenny C.M. Chan +4 more
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A Dynamic Quantitative Microbial Risk Assessment for Norovirus in Potable Reuse System [PDF]
, 2019 This study describes the results of a dynamic quantitative microbial risk assessment (QMRA) for norovirus (NoV) that was used to evaluate the relative significance of foodborne, person-to-person, and person-to-sewage-to-person transmission pathways. This
Ahmad, Sajjad +3 more
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