Results 71 to 80 of about 38,742 (265)

Conformational changes in human Norovirus polymerase [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Human Noroviruses (NV) belong in the Caliciviridae family and are a major cause of gastroenteritis outbreaks throughout the world. Crystal structures of the RNA-dependent RNA polymerase from the human Norovirus have been determined in over ten different crystal forms in the presence and absence of divalent metal cations, nucleoside triphosphates ...
Kenneth Ng, Dmitry Zamyatkin, Hayeong Rho, Elesha Hoffarth, Gabriela Jurca, Andrew Cottle, Dean Lang, Vinay Sohal, Julia Savtchouk, Francisco Parra   +9 more
openaire   +1 more source

Interferon-lambda: A potent regulator of intestinal viral infections [PDF]

, 2017
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
core   +3 more sources

Medical Gas Plasma Inactivates Adenoviruses via Capsid Oxidation

Small, EarlyView.
Oxidative modification of three adenoviral capsid proteins after gas plasma treatment. Schematic representation of the viral infection process, starting with the initial attachment of the virus via its fiber protein binding to the cellular receptors (CAR and/or CD46). In the secondary attachment step, the penton base binds to integrin structures on the
Anke Schmidt, Meike Heuser, Paul Schulan, Lea Miebach, Alice Martinet, Marcus Frank, Kristian Wende, Sander Bekeschus   +7 more
wiley   +1 more source

Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation

eLife, 2019
Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a CRISPR screen,
Myra Hosmillo, Jia Lu, Michael R McAllaster, James B Eaglesham, Xinjie Wang, Edward Emmott, Patricia Domingues, Yasmin Chaudhry, Tim J Fitzmaurice, Matthew KH Tung, Marc Dominik Panas, Gerald McInerney, Nicolas Locker, Craig B Wilen, Ian G Goodfellow   +14 more
doaj   +1 more source

Lack of Effect of Murine Norovirus Infection on a Mouse Model of Bacteria-Induced Colon Cancer [PDF]

, 2011
Murine norovirus (MNV) is endemic in mouse research facilities in the United States and Europe, with a prevalence as high as 58% to 64%. Because of MNV's orofecal route of infection, clinically silent persistent infections in some mouse strains, and ...
Brabb, Thea, Drivdahl, Rolf, Lencioni, Karen C., Maggio-Price, Lillian, Seamons, Audrey, Treuting, Piper M.   +5 more
core   +1 more source

Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. [PDF]

, 2018
Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds
Emmott, Edward, Goodfellow, Ian, Hosmillo, Myra, Kitano, Mitsutaka, Lu, Jia   +4 more
core   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Survey of Norovirus in oysters collected from commercial harvesting farm in Fujian Province

Zhongguo shipin weisheng zazhi, 2021
Objective The contamination rate and gene groups of Norovirus(NoV) in oyster collected from harvesting farm in Fujian Province was investigated, and the contamination concentration was quantitatively analyzed, so as to provide data support for ...
Xuejie LIU, Minzhen LI, Lingqing YE, Yixin FU, Weiwei CHEN   +4 more
doaj   +1 more source

Adjuvant therapy of severe and/or refractory bullous pemphigoid with immunoadsorption – A prospective monocenter pilot study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Bullous pemphigoid (BP) is the most common autoimmune blistering disease in the Western world. While remission is achieved in the majority of BP patients by long‐term use of corticosteroids with or without immunomodulants/immunosuppressants, national and international guidelines recommend adjuvant immunoadsorption (IA)
Maike M. Holtsche, Nina van Beek, Christoph M. Hammers, Artem Vorobyev, Michael Kasperkiewicz, Nina Schumacher, Philip Muck, Enno Schmidt   +7 more
wiley   +1 more source

The Importance of Secretor-Status in Norovirus Infection Following Allogeneic Hematopoietic Stem Cell Transplantation

Viruses, 2022
Background. Human secretor-status is a strong susceptibility factor for norovirus infection in immunocompetent people. The predominant norovirus genotype GII.4 almost exclusively infects secretors and is also associated with more severe symptoms. However,
Lisa Swartling, Elda Sparrelid, Per Ljungman, Ksenia Boriskina, Davide Valentini, Lennart Svensson, Johan Nordgren   +6 more
doaj   +1 more source