Results 1 to 10 of about 54,530 (132)

T-Cell Therapeutics Targeting Human Parainfluenza Virus 3 Are Broadly Epitope Specific and Are Cross Reactive With Human Parainfluenza Virus 1 [PDF]

Frontiers in Immunology, 2020
Human Parainfluenza Virus-3 (HPIV3) causes severe respiratory illness in immunocompromised patients and lacks approved anti-viral therapies. A phase I study of adoptively transferred virus-specific T-cells (VSTs) targeting HPIV3 following bone marrow ...
Katherine M. Harris, Katherine M. Harris, Sarah E. Horn, Melanie L. Grant, Haili Lang, Gelina Sani, Mariah A. Jensen-Wachspress, Vaishnavi V. Kankate, Anushree Datar, Christopher A. Lazarski, Catherine M. Bollard, Catherine M. Bollard, Catherine M. Bollard, Michael D. Keller, Michael D. Keller, Michael D. Keller   +15 more
doaj   +2 more sources

Human parainfluenza virus surveillance in pediatric patients with lower respiratory tract infections: a special view of parainfluenza type 4

Jornal de Pediatria (Versão em Português), 2018
Objective: Characterize the role of human parainfluenza virus and its clinical features in Brazilian children under 2 years of age presenting with acute lower respiratory tract infections.
Luciano M. Thomazelli, Danielle B.L. de Oliveira, Giuliana S. Durigon, Brett Whitaker, Shifaq Kamili, Eitan N. Berezin, Edison L. Durigon   +6 more
doaj   +7 more sources

Leveraging human precision cut lung slices for the study of human parainfluenza virus 3 infection [PDF]

Respiratory Research
Human parainfluenza virus 3 is a highly abundant RNA virus that primarily affects young children, the elderly, and immunocompromised individuals, leading to severe lower respiratory infections and pneumonia.
Olga Danov, Philippe Vollmer Barbosa, Helena Obernolte, Maximilian Fuchs, Patrice Guillon, Larissa Dirr, Ibrahim El-Deeb, Meik Kunz, Leonie Hose, Gaël Martin, Fabian Röpken, Anna Zimmer, Lavinia Neubert, Danny Jonigk, Hans-Gerd Fieguth, Franziska Dahlmann, Sabine Wronski, Mark von Itzstein, Thomas Tschernig, Armin Braun, Katherina Sewald   +20 more
doaj   +2 more sources

Human parainfluenza virus 3 fusion protein cleavage: a key determinant of infection and spread [PDF]

Journal of Virology
Human parainfluenza virus 3 (HPIV3) entry into target cells depends on a viral fusion complex composed of hemagglutinin-neuraminidase (HN) and fusion protein (F).
Kyle Stearns, Tara Marcink, Emily Pawlack, Elizabeth B. Sobolik, Matteo Porotto, Alexander L. Greninger, Stefan Nieweisk, Anne Moscona   +7 more
doaj   +2 more sources

Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry [PDF]

mBio
Human parainfluenza virus 3 (HPIV3) infection is driven by the coordinated action of viral surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion protein (F).
Kyle Stearns, George Lampe, Rachel Hanan, Tara Marcink, Stefan Niewiesk, Samuel H. Sternberg, Alexander L. Greninger, Matteo Porotto, Anne Moscona   +8 more
doaj   +2 more sources

Protective antibodies against human parainfluenza virus type 3 infection

mAbs, 2021
Human parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. There are currently no effective vaccines or therapeutics available, resulting
Jim Boonyaratanakornkit, Suruchi Singh, Connor Weidle, Justas Rodarte, Ramasamy Bakthavatsalam, Jonathan Perkins, Guillaume B.E. Stewart-Jones, Peter D. Kwong, Andrew T. McGuire, Marie Pancera, Justin J. Taylor   +10 more
doaj   +1 more source

The Clinical Performance of the BioCode Respiratory Pathogen Panel for the Detection of Viruses and Bacteria from Nasopharyngeal Swabs

Microbiology Spectrum, 2023
Early detection of microbial pathogens causing respiratory tract infection plays a crucial role in clinical management. The BioCode Respiratory Pathogen Panel (BioCode RPP) utilizes reverse transcriptase PCR (RT-PCR) in combination with barcoded magnetic
Xin Zhang, Colleen Knoth, Anh Pham, Amorce Lima, Rosario Dominguez, Irvin Ibarra-Flores, Juan C. Lopez, Dominic Uy, Suzane Silbert, Anami Patel, Michael Aye, Yi-Wei Tang, Jennifer Dien Bard   +12 more
doaj   +1 more source

Modeling Infection and Tropism of Human Parainfluenza Virus Type 3 in Ferrets

mBio, 2022
Human parainfluenza virus type 3 (HPIV-3) is a significant cause of lower respiratory tract infections, with the most severe disease in young infants, immunocompromised individuals, and the elderly.
Laurine C. Rijsbergen, Katharina S. Schmitz, Lineke Begeman, Jennifer Drew-Bear, Lennert Gommers, Mart M. Lamers, Alexander L. Greninger, Bart L. Haagmans, Matteo Porotto, Rik L. de Swart, Anne Moscona, Rory D. de Vries   +11 more
doaj   +1 more source

CIRCULATING PATTERN OF RESPIRATORY VIRUSES, IN EGYPT, SEASON 2013-2014 [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2020
Respiratory viruses causes lower and upper respiratory tract infections; LRTIs and URTIs. These infections are from the predominant causes of infections, especially in children and infants.
Yara Shamikh, Ibrahim Elsayed, Amel Naguib, Wael Roshdy   +3 more
doaj   +1 more source

Identification of a natural human serotype 3 parainfluenza virus

Virology Journal, 2011
Parainfluenza virus is an important pathogen threatening the health of animals and human, which brings human many kinds of disease, especially lower respiratory tract infection involving infants and young children.
Wang Xiao-Jing, Si Hong-Li, Bai Mu-Qun, Zhou Xu, Jiang Qing, Yang Hui-Ting, Lu Yan, Zhao Heng, He Hong-Bin, He Cheng-Qiang   +9 more
doaj   +1 more source