Results 1 to 10 of about 159,014 (249)

T-Cell Therapeutics Targeting Human Parainfluenza Virus 3 Are Broadly Epitope Specific and Are Cross Reactive With Human Parainfluenza Virus 1 [PDF]

Frontiers in Immunology, 2020
Human Parainfluenza Virus-3 (HPIV3) causes severe respiratory illness in immunocompromised patients and lacks approved anti-viral therapies. A phase I study of adoptively transferred virus-specific T-cells (VSTs) targeting HPIV3 following bone marrow ...
Katherine M. Harris, Katherine M. Harris, Sarah E. Horn, Melanie L. Grant, Haili Lang, Gelina Sani, Mariah A. Jensen-Wachspress, Vaishnavi V. Kankate, Anushree Datar, Christopher A. Lazarski, Catherine M. Bollard, Catherine M. Bollard, Catherine M. Bollard, Michael D. Keller, Michael D. Keller, Michael D. Keller   +15 more
doaj   +6 more sources

Immunoinformatics-aided rational design of multiepitope-based peptide vaccine (MEBV) targeting human parainfluenza virus 3 (HPIV-3) stable proteins. [PDF]

J Genet Eng Biotechnol, 2023
Human parainfluenza viruses (HPIVs) are common RNA viruses responsible for respiratory tract infections. Human parainfluenza virus 3 (HPIV-3) is particularly pathogenic, causing severe illnesses with no effective vaccine or therapy available. The current
Hossen MS, Hasan MN, Haque M, Al Arian T, Halder SK, Uddin MJ, Abdullah-Al-Mamun M, Shakil MS.   +7 more
europepmc   +2 more sources

Structural Basis of Human Parainfluenza Virus 3 Unassembled Nucleoprotein in Complex with Its Viral Chaperone. [PDF]

J Virol, 2022
Human parainfluenza virus 3 (HPIV3) causes annual epidemics of respiratory diseases, especially in newborns and infants. For the replication of HPIV3 and other paramyxoviruses, only three viral proteins are required: phosphoprotein (P), RNA polymerase (L)
Dong X, Wang X, Xie M, Wu W, Chen Z.
europepmc   +2 more sources

Human Parainfluenza Virus 3 Phosphoprotein Is a Tetramer and Shares Structural and Interaction Features with Ebola Phosphoprotein VP35. [PDF]

Biomolecules, 2021
The human parainfluenza virus 3 (HPIV3) poses a risk for pneumonia development in young children and immunocompromised patients. To investigate mechanisms of HPIV3 pathogenesis, we characterized the association state and host protein interactions of ...
Rodriguez Galvan J, Donner B, Veseley CH, Reardon P, Forsythe HM, Howe J, Fujimura G, Barbar E.   +7 more
europepmc   +2 more sources

A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms. [PDF]

Antiviral Res, 2020
Stimulator of interferon genes (STING), as a signaling hub in innate immunity, plays a central role for the effective initiation of host defense mechanisms against microbial infections.
Zhu Q, Hu H, Liu H, Shen H, Yan Z, Gao L.   +5 more
europepmc   +2 more sources

The Sialic Acid Binding Activity of Human Parainfluenza Virus 3 and Mumps Virus Glycoproteins Enhances the Adherence of Group B Streptococci to HEp-2 Cells. [PDF]

Front Cell Infect Microbiol, 2018
In the complex microenvironment of the human respiratory tract, different kinds of microorganisms may synergistically interact with each other resulting in viral-bacterial co-infections that are often associated with more severe diseases than the ...
Tong J, Fu Y, Meng F, Krüger N, Valentin-Weigand P, Herrler G.   +5 more
europepmc   +2 more sources

Rapid Metagenomic Next-Generation Sequencing during an Investigation of Hospital-Acquired Human Parainfluenza Virus 3 Infections. [PDF]

J Clin Microbiol, 2017
Metagenomic next-generation sequencing (mNGS) is increasingly used for the unbiased detection of viruses, bacteria, fungi, and eukaryotic parasites in clinical samples. Whole-genome sequencing (WGS) of clinical bacterial isolates has been shown to inform
Greninger AL, Zerr DM, Qin X, Adler AL, Sampoleo R, Kuypers JM, Englund JA, Jerome KR.   +7 more
europepmc   +2 more sources

Leveraging human precision cut lung slices for the study of human parainfluenza virus 3 infection [PDF]

Respiratory Research
Human parainfluenza virus 3 is a highly abundant RNA virus that primarily affects young children, the elderly, and immunocompromised individuals, leading to severe lower respiratory infections and pneumonia.
Olga Danov, Philippe Vollmer Barbosa, Helena Obernolte, Maximilian Fuchs, Patrice Guillon, Larissa Dirr, Ibrahim El-Deeb, Meik Kunz, Leonie Hose, Gaël Martin, Fabian Röpken, Anna Zimmer, Lavinia Neubert, Danny Jonigk, Hans-Gerd Fieguth, Franziska Dahlmann, Sabine Wronski, Mark von Itzstein, Thomas Tschernig, Armin Braun, Katherina Sewald   +20 more
doaj   +2 more sources

Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry [PDF]

mBio
Human parainfluenza virus 3 (HPIV3) infection is driven by the coordinated action of viral surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion protein (F).
Kyle Stearns, George Lampe, Rachel Hanan, Tara Marcink, Stefan Niewiesk, Samuel H. Sternberg, Alexander L. Greninger, Matteo Porotto, Anne Moscona   +8 more
doaj   +2 more sources

Respiratory Viral Co-Infections in SARS-CoV-2 Positive Patients in Burkina Faso: A Cross-Sectional Study. [PDF]

Health Sci Rep
ABSTRACT Background The burden of viral co‐infections among COVID‐19 patients is underexplored in low‐resource settings such as Burkina Faso. This study aimed to determine the prevalence and associated factors of respiratory viral co‐infections among laboratory‐confirmed COVID‐19 patients. Methods A cross‐sectional study was conducted from January 1 to
Kaboré BWO, Gouba N, Ilboudo AK, Cissé A, Lingani M, Sawadogo C, Ouédraogo EW, Ouoba JB, Savadogo M, Tarnagda Z.   +9 more
europepmc   +2 more sources