Results 91 to 100 of about 427,356 (313)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Breast support garments are ineffective at reducing breast motion during an aqua aerobics jumping exercise [PDF]

, 2015
The buoyant forces of water during aquatic exercise may provide a form of ‘natural’ breast support and help to minimise breast motion and alleviate exercise induced breast pain. Six larger-breasted females performed standing vertical land and water-based
Ayres, Bessie, Mills, Chris, Scurr, Joanna Claire   +2 more
core   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Effects of Therapies Involving Plyometric-Jump Training on Physical Fitness of Youth with Cerebral Palsy: A Systematic Review with Meta-Analysis

Sports
The aim of this systematic review was to assess the effects of plyometric-jump training (PJT) on the physical fitness of youth with cerebral palsy (CP) compared with controls (i.e., standard therapy). The PRISMA 2020 guidelines were followed. Eligibility
Exal Garcia-Carrillo, Rodrigo Ramirez-Campillo, Mikel Izquierdo, Ragab K. Elnaggar, José Afonso, Luis Peñailillo, Rodrigo Araneda, Daniela Ebner-Karestinos, Urs Granacher   +8 more
doaj   +1 more source

The Volatility Curse: Revisiting the Paradox of Plenty [PDF]

The volatility of unanticipated output growth in income per capita is detrimental to long-run development, controlling for initial income per capita, population growth, human capital, investment, openness and natural resource dependence.
Frederick Van der Ploeg, Steven Poelhekke   +1 more
core  

Examining affective structure in chickens: valence, intensity, persistence and generalization measured using a conditioned place preference test [PDF]

, 2018
When measuring animals’ valenced behavioural responses to stimuli, the Conditioned Place Preference (CPP) test goes a step further than many approach-based and avoidance-based tests by establishing whether a learned preference for, or aversion to, the ...
Caplen, G, Edgar, J L, Nicol, C J, Paul, E S   +3 more
core   +4 more sources

Phy-Tac: Toward Human-Like Grasping via Physics-Conditioned Tactile Goals

Humans naturally grasp objects with minimal level required force for stability, whereas robots often rely on rigid, over-squeezing control. To narrow this gap, we propose a human-inspired physics-conditioned tactile method (Phy-Tac) for force-optimal stable grasping (FOSG) that unifies pose selection, tactile prediction, and force regulation. A physics-
Lyu, Shipeng, Sheng, Lijie, Wang, Fangyuan, Zhang, Wenyao, Lin, Weiwei, Jia, Zhenzhong, Navarro-Alarcon, David, Guo, Guodong   +7 more
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Two-layer energy optimization of HVAC system in a cement factory building

Sustainable Energy Research
Based on the building thermodynamics model and the physical heat/cold conversion model of an air-conditioning system, this paper proposes a double-layer energy optimization model for a cement factory’s office building air-conditioning systems considering
Xiaoquan Lu, Kaijie Fang, Yuqi Zhou, Ju Sheng, Hanmiao Chen   +4 more
doaj   +1 more source