Results 241 to 250 of about 1,669,866 (339)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Understanding oxytocin in human physiology and pathophysiology: A path towards therapeutics. [PDF]

Compr Psychoneuroendocrinol
Lawson EA.
europepmc   +1 more source

Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology. [PDF]

Int J Mol Sci, 2020
Samodelov SL, Kullak-Ublick GA, Gai Z, Visentin M.   +3 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Revitalising Riboflavin: Unveiling Its Timeless Significance in Human Physiology and Health. [PDF]

Foods
Aragão MÂ, Pires L, Santos-Buelga C, Barros L, Calhelha RC.   +4 more
europepmc   +1 more source

In sickness and health: Effects of gut microbial metabolites on human physiology. [PDF]

PLoS Pathog, 2020
Glowacki RWP, Martens EC.
europepmc   +1 more source

Biomechanical insights into the regulatory effect of light on residents’ emotions and physiological rhythms in human living environment

Jingyi Wang, Li Han, Yan Song, Haozhong Yang, Minglan Zou   +4 more
openalex   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Myths and methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research. [PDF]

Exp Physiol
Wrench E, Subar DA, Bampouras TM, Lauder RM, Gaffney CJ.   +4 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source