Results 61 to 70 of about 1,669,866 (339)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prevalence of Erectile Dysfunction and Associated Factors among Hypertensive Patients Attending Governmental Health Institutions in Gondar City, Northwest Ethiopia: A Cross-Sectional Study

International Journal of Hypertension, 2021
Introduction. Erectile dysfunction is a common sexual problem affecting men with hypertension. It may result in withdrawal from sexual engagement, decreased work productivity, psychosocial problems including poor self-esteem and depression, and reduction
Deribew Abebaw Abuhay, Yibeltal Yismaw Gela, Ayechew Adera Getu   +2 more
doaj   +1 more source

Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine [PDF]

, 2019
Background: The upper gastrointestinal tract plays a prominent role in human physiology as the primary site for enzymatic digestion and nutrient absorption, immune sampling, and drug uptake.
Bogatyrev, Said R., Ismagilov, Rustem F., Rolando, Justin C.   +2 more
core   +1 more source

Evaluation of the Hybrid Learning Model to Teach Human Physiology Experiments [PDF]

, 2023
MG Kamath, Rizwan Qaisar, Asima Karim, Adel B. Elmoselhi, Bashair M. Mussa   +4 more
openalex   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk

iScience
Summary: In-utero and dietary factors make important contributions toward health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases, which together with ...
Santosh D. Bhosale, Robert Moulder, Tomi Suomi, Terhi Ruohtula, Jarno Honkanen, Suvi M. Virtanen, Jorma Ilonen, Laura L. Elo, Mikael Knip, Riitta Lahesmaa   +9 more
doaj   +1 more source

Elevated arousal at time of decision-making is not the arbiter of risk avoidance in chickens [PDF]

, 2015
The somatic marker hypothesis proposes that humans recall previously experienced physiological responses to aid decision-making under uncertainty. However, little is known about the mechanisms used by non-human animals to integrate risk perception with ...
A Bechara, A Bechara, A Bechara, AC Davies, AC Davies, AL Krain, AR Damasio, B Studer, CJ Burke, DJ McFarland, EA Crone, GF Loewenstein, HD Critchley, I Cuthill, JA Weller, JC Lowe, JL Edgar, JL Edgar, L Chittka, M Mendl, PC Trimmer, PH Zimmerman, RO Moe, RO Moe, S Korte, SL Lima, T Caraco, WJ Browne, X Cerda   +28 more
core   +4 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Commentary: Direct estimation of central aortic pressure from measured or quantified mean and diastolic brachial blood pressure: agreement with invasive records

Frontiers in Cardiovascular Medicine, 2023
Denis Chemla, Denis Chemla, Mathieu Jozwiak, Mathieu Jozwiak   +3 more
doaj   +1 more source

"A Vessel Divinely Molded": Basil of Caesarea on the Human Body [PDF]

, 2017
This paper has two parts. First, I examine Basil of Caesarea’s theological anthropology and show how he understands the human being as a body-soul unity. The body is the good instrument of the soul. It is marvelous because it has been molded by God’s own
Adam Rasmussen
core   +1 more source