Results 111 to 120 of about 8,929,794 (358)

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

New applications of sustainable, scalable, standardized, and cost-effective human biomaterials for cell-based assays, tissue engineering, and regenerative medicine

Frontiers in Bioengineering and Biotechnology
Human-derived biomaterials offer several advantages over animal-derived or synthetic alternatives, including improved biocompatibility, ethical acceptability, sustainability, and clinical translatability.
Rebekka J. S. Salzmann, Rebekka J. S. Salzmann, Sandra Domazet, Sandra Domazet, Sonia Prado-López, Seyda Kigili, Winfried Neuhaus, Winfried Neuhaus, Andreas Brachner, Gerda Egger, Gerda Egger, Lorenzo Moroni, Johannes Hackethal, Johannes Hackethal   +13 more
doaj   +1 more source

Uterine natural killer cell heterogeneity: Lessons from mouse models [PDF]

, 2020
Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes.
Sojka, Dorothy K
core   +1 more source

Placental DEPTOR as a stress sensor during pregnancy [PDF]

, 2011
The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Gidron, Y, Goumenou, A, Karteris, E, Mparmpakas, D, Zachariades, E   +4 more
core   +2 more sources

Pervasive polymorphic imprinted methylation in the human placenta

Genome Research, 2016
The maternal and paternal copies of the genome are both required for mammalian development, and this is primarily due to imprinted genes, those that are monoallelically expressed based on parent-of-origin.
C. Hanna, M. Peñaherrera, Heba Saadeh, S. Andrews, D. McFadden, G. Kelsey, W. Robinson   +6 more
semanticscholar   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease

Frontiers in Cardiovascular Medicine
Placental function plays a crucial role in fetal development, as it serves as the primary interface for delivery of nutrients and oxygen from the mother to fetus.
Eric Sadiku, Eric Sadiku, Liqun Sun, Liqun Sun, Christopher K. Macgowan, Christopher K. Macgowan, Mike Seed, Mike Seed, Mike Seed, Mike Seed, Mike Seed, Janna L. Morrison, Janna L. Morrison, Janna L. Morrison   +13 more
doaj   +1 more source

COVID‐19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS‐CoV‐2 infection [PDF]

, 2021
Max Arran Beesley, JR Davidson, Francesco Panariello, Soichi Shibuya, Dominic Scaglioni, Brendan C. Jones, Kasia Maksym, Oluwaseun Ogunbiyi, Neil J. Sebire, Davide Cacchiarelli, Anna L. David, Paolo De Coppi, M Gerli   +12 more
openalex   +1 more source

Mythology and destiny [PDF]

, 2005
In Albanian tradition, the essential attributes of the mythological figures of destiny seem to be symbolic interchangeable representations of birth itself. In addition, their mythical combat is but the symbolic representation of the cyclic return in the
Doja, A.
core   +2 more sources