Results 121 to 130 of about 8,929,794 (358)

Zika virus productively infects primary human placenta-specific macrophages.

JCI Insight, 2016
The strong association of Zika virus infection with congenital defects has led to questions of how a flavivirus is capable of crossing the placental barrier to reach the fetal brain.
K. Jurado, M. Simoni, Zhonghua Tang, Ryuta Uraki, Jesse Hwang, Sarah Householder, Ming-Jie Wu, B. Lindenbach, V. Abrahams, S. Guller, E. Fikrig   +10 more
semanticscholar   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Comparing placentas from normal and abnormal pregnancies [PDF]

, 2010
This report describes work carried out at a Mathematics-in-Medicine Study Group. It is believed that placenta shape villous network characteristics are strongly linked to the placenta’s efficiency, and hence to pregnancy outcome.
Cotter, SL, Gallimore, L., Greenhalgh, David, Heazell, Alexander, Kennedy, S., Klika, V., Kritz, M., Nelson, P., Preedy, Katharine, Pu, I., Siggers, J., Stechi, A., Whittaker, R.   +12 more
core  

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]

, 2019
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang, Fang-Hoover, June, Freed, Daniel C, Fu, Tong-Ming, Li, Fengsheng, Pereira, Lenore, Petitt, Matthew, Tabata, Takako, Wang, Dai   +8 more
core   +1 more source

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

Scientific Reports, 2016
Interaction with intestinal microbes in infancy has a profound impact on health and disease in later life through programming of immune and metabolic pathways.
M. Collado, S. Rautava, J. Aakko, E. Isolauri, S. Salminen   +4 more
semanticscholar   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Morphology of the villous chorion maldevelopment in early forms of EPH-gestosis combined with anemia of pregnancy

Patologìâ, 2012
On the basis of a complex morphological study of human placenta the characteristic structural features of villous maldevelopment in a combination of edema of pregnant and anemia of pregnancy are defined by the type of dissociated cotyledon development ...
N. M. Lagoda
doaj   +1 more source

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates [PDF]

, 2014
BB/H012494/1/ Biotechnology and Biological Sciences Research ...
Barg E, Bejamini Y, Chris Mathews, David J Williams, Graham A Hitman, Melissa C Smart, Robert Lowe, Sara L Hillman, Sarah Finer, Smyth GK, Vardhman K Rakyan   +10 more
core   +3 more sources

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source