Results 321 to 330 of about 8,792,528 (401)

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

open access: yesMedicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che   +3 more
wiley   +1 more source

P4‐ATPases as Phospholipid Flippases: From Membrane Dynamics to Human Disorders

open access: yesMedicine Bulletin, EarlyView.
ABSTRACT P4‐ATPases (P4 subfamily of P‐type ATPases) flippase complex includes an α‐subunit responsible for catalysis and a supporting β‐subunit, which consumes energy by catalyzing the hydrolysis of ATP, thereby facilitating the translocation of aminophospholipids from the outer to the inner leaflet of cellular membranes to maintain the asymmetric ...
Guangyi Chen, Yeming Yang, Xianjun Zhu
wiley   +1 more source

The Management of Parkinson's Disease Before, during and after Pregnancy—an MDS Scientific Issues Committee Review

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Pregnancy after a Parkinson's diagnosis presents complex challenges. Due to the paucity of literature, there is no evidence‐based guidelines and protocols for preconception care, management of pregnancy, childbirth and the postpartum period in women with early‐onset Parkinson's disease (PD).
Alexander C. Lehn   +18 more
wiley   +1 more source

RSA‐KG: A Graph‐Based Rag Enhanced AI Knowledge Graph for Recurrent Spontaneous Abortions Diagnosis and Clinical Decision Support

open access: yesMed Research, EarlyView.
RSA‐KG, a graph‐based AI knowledge graph, integrates multimodal clinical data from international RSA guidelines. It outperforms naive RAG and raw models in diagnostic accuracy, aiding RSA diagnosis and clinical decision‐making. ABSTRACT Recurrent spontaneous abortion (RSA), affecting 1%–5% of reproductive‐aged women, presents diagnostic challenges due ...
Yibo He   +13 more
wiley   +1 more source

Receptor usage of Syncytin-1: ASCT2, but not ASCT1, is a functional receptor and effector of cell fusion in the human placenta. [PDF]

open access: yesProc Natl Acad Sci U S A
Štafl K   +10 more
europepmc   +1 more source

Bifidobacterium animalis subsp. Lactis BL‐99 Improves Maternal and Fetal Immune Responses and Pregnancy Outcomes in Pregnant Antibiotics‐Treated Mice

open access: yesMolecular Nutrition &Food Research, EarlyView.
Pregnant mice treated with antibiotics showed gut dysbiosis, which is associated with reduced fetal and placental weight, and disrupted maternal and fetal immune responses. Supplementation via oral gavage with Bifidobacterium animalis subsp. lactis BL‐99 increased B. animalis levels in the gut, but did not fully restore microbiome balance.
Marijke M. Faas   +6 more
wiley   +1 more source

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