Results 61 to 70 of about 8,929,794 (358)

The effect of maternal iron deficiency on zinc and copper levels and on genes of zinc and copper metabolism during pregnancy in the rat [PDF]

, 2019
Fe deficiency is relatively common in pregnancy and has both short- and long-term consequences. However, little is known about the effect on the metabolism of other micronutrients.
Cottin, Sarah C., Currie, Valerie J., Gambling, Lorraine, Hayes, Helen E., McArdle, Harry J., Roussel, Guenievre   +5 more
core   +5 more sources

Drug transport across the human placenta: review of placenta-on-a-chip and previous approaches

Interface Focus, 2019
In the past few decades, the placenta became a very controversial topic that has had many researchers and pharmacists discussing the significance of the effects of pharmaceutical drug intake and how it is a possible leading cause towards birth defects ...
Rajeendra L. Pemathilaka, David E. Reynolds, Nicole N. Hashemi   +2 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H2S Biogenesis and the Effects Are Transmitted Transgenerationally

Frontiers in Immunology, 2020
Rationale: Gestational cigarette smoke (CS) impairs lung angiogenesis and alveolarization, promoting transgenerational development of asthma and bronchopulmonary dysplasia (BPD).
Shashi P. Singh, Dinesh Devadoss, Marko Manevski, Aryaz Sheybani, Teodora Ivanciuc, Vernat Exil, Hemant Agarwal, Veena Raizada, Roberto P. Garofalo, Hitendra S. Chand, Mohan L. Sopori   +10 more
doaj   +1 more source

MR imaging–derived oxygen-hemoglobin dissociation curves and fetal-placental oxygen-hemoglobin affinities [PDF]

, 2016
PURPOSE: To generate magnetic resonance (MR) imaging–derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level–dependent (BOLD) T2* and oxygen ...
Akselrod-Ballin, Ayelet, Avni, Reut, Biton, Inbal, Cohen, Yonni, Garbow, Joel R, Golani, Ofra, Neeman, Michael   +6 more
core   +2 more sources

Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta

Nature Protocols, 2018
The human placenta is essential for successful reproduction. There is great variation in the anatomy and development of the placenta in different species, meaning that animal models provide limited information about human placental development and ...
M. Sheridan, R. Fernando, L. Gardner, M. Hollinshead, G. Burton, A. Moffett, M. Turco   +6 more
semanticscholar   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Prolactin decreases LPS-induced inflammatory cytokines by inhibiting TLR-4/NFκB signaling in the human placenta

Molecular human reproduction, 2019
Prolactin (PRL) plays an important role in trophoblast growth, placental angiogenesis and immunomodulation within the feto-maternal interface, where different cell types secrete PRL and express its receptor. During pregnancy, inflammatory signalling is a
A. Olmos-Ortíz, M. Déciga-García, E. Preciado-Martínez, L. Bermejo-Martínez, P. Flores-Espinosa, Ismael Mancilla-Herrera, C. Irles, A. C. Helguera-Repetto, B. Quesada-Reyna, Goffin, L. Díaz, Zaga-Clavellina   +11 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta

Frontiers in Endocrinology, 2023
IntroductionLipids and fatty acids are key components in metabolic processes of the human placenta, thereby contributing to the development of the fetus.
Natascha Berger, Tom van der Wel, Birgit Hirschmugl, Birgit Hirschmugl, Thomas Baernthaler, Juergen Gindlhuber, Juergen Gindlhuber, Nermeen Fawzy, Thomas Eichmann, Thomas Eichmann, Ruth Birner-Gruenberger, Ruth Birner-Gruenberger, Robert Zimmermann, Robert Zimmermann, Mario van der Stelt, Christian Wadsack, Christian Wadsack   +16 more
doaj   +1 more source