Results 31 to 40 of about 10,145,519 (298)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Rights and responsibilities: consultation report [PDF]

, 2015
Rights & Responsibilities 2014 was a national consultation conducted by the Human Rights Commissioner between August and December 2014. The consultation examined how well people think their human rights and freedoms are protected in Australia ...
Australian Human Rights Commission
core  

The UN Supply Chain Treaty Negotiations: Between Transnational Civil Litigation and Public Law Beyond Borders

AJIL Unbound
The negotiations on a treaty to regulate global supply chains and their impact on human rights will hold its tenth session in December 2024. The question the negotiations address is not completely new: previous efforts, starting in the 1970s at the ...
Humberto Cantú Rivera
doaj   +1 more source

Extraterritorial application of the right to life on the high sea . Commentary to the Views adopted by the Human Rights Committee of 27 January 2021, A.S., D.I., O.I. and G.D. against Italy, Communication No. 3042/2017

Studia Prawnicze KUL, 2021
The subject matter of this commentary, which instigates the Views of the Human Rights Committee of 27 January 2021, is the protection of one of the fundamental human rights – the right to life.
Bartosz Pacholski
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Balancing Individual and Collective Rights: Implementation of Section 1.2 of The Canadian Human Rights Act [PDF]

, 2009
Implementation of section 1.2 of the Canadian Human Rights ...
Groves, Robert, Morse, Bradford, Vermette, D'Arcy   +2 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Should politicians be prosecute for statements made in the exercise of their mandate?

Crítica Penal y Poder, 2019
http://assembly.coe.int/nw/xml/XRef/Xref-XML2HTML-en.asp?fileid=25279&lang=en http://assembly.coe.int/nw/xml/XRef/Xref-XML2HTML-FR.asp?fileid=25279&lang ...
Boris Cilevičs, Committee on Legal Affairs and Human Rights
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source