Results 41 to 50 of about 10,145,519 (298)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2021 The Center's 2020-2021 Annual Review highlights our long-term project on human rights, social justice, and inequality, with a new focus on the past, present, and future of work.
Rapoport Center for Human Rights and Justice
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Is Britain Fairer?: The State of Equality and Human Rights in Britain [PDF]
, 2015 This is our five-yearly report on equality and human rights progress in Great Britain. The report sets out our findings and the challenges for the future in the following areas: - education and learning - work, income and the economy - health and care -
Equality and Human Rights Commission,
core
Age of Human Rights Journal, 2017 The aim of this article is to carry out an in-depth analysis of Article 7, “Children with disabilities”, of the Convention on the Rights of Persons with Disabilities.
Ignacio Campoy Cervera
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Oral Evidence Given at Joint Committee on Human Rights, Westminster
Oral Evidence Session at Joint Committee on Human Rights ...
Lane, Michael
core +4 more sources
Human rights abuses at a psychiatric hospital in KwaZulu-Natal
South African Journal of Psychiatry, 2007 Background:Following allegations of human rights abuses ata psychiatric hospital in Pietermaritzburg, KwaZulu-Natal, thatwere reported in one of the local newspapers, the nationaland provincial Ministers of Health visited the hospital.
D L Mkhize
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The European Committee of Social Rights in the system of International Human Rights Treaty Bodies
Przegląd Prawniczy Uniwersytetu im. Adama Mickiewicza, 2014 The aim of this article is to present the European Committee of Social Rights as a supervisory body in the system of international protection of human rights.
Aleksander Gadkowski
doaj +1 more source