Results 21 to 30 of about 89,677 (261)

Mainstreaming Human Rights Education: What’s Radical About That?

Radical Teacher, 2016
One of the most radical ways of teaching about universal human rights and international humanitarian law would be to teach about these fundamental internationally-recognized standards for humane interpersonal conduct to every child who enters school in ...
Rosemary Ann Blanchard
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Rural response system to prevent violence against women: methodology for a community randomised controlled trial in the central region of Ghana

Global Health Action, 2019
Violence against women (VAW) is common in Ghana, with nation-wide surveys reporting high prevalence of intimate partner violence (IPV) (physical, sexual and/or emotional violence).
Adolphina A. Addo-Lartey, Deda Ogum Alangea, Yandisa Sikweyiya, Esnat D. Chirwa, Dorcas Coker-Appiah, Rachel Jewkes, Richard M. K. Adanu   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Establishment of the Council of Europe’s activities on the protection of human rights and freedoms

Bulletin of Kharkiv National University of Internal Affairs
The article is devoted to the process of the establishment of the Council of Europe's activities in the field of human rights and freedoms protection. The historical context of the creation of this organisation after the Second World War is analysed, in ...
L. L. Honcharenko
doaj   +1 more source

A comparative study of Iran legal order in facing the guiding principles of business and human rights (john ruggie Principles) approved in 2011 [PDF]

پژوهشنامه حقوق تطبیقی
Nowadays, in line with the increasing economic power of commercial companies, including multinational and transnational companies, and their commercial acts¢ impacts on human rights, states can no longer be considered the only human rights violators ...
Eisa Rajabi, Shahriar Kazemi Azar, Mohammad Farzanegan   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

UKRAINIAN LOCAL GOVERNMENT, HUMAN RIGHTS PROTECTION AND COUNCIL OF EUROPE STANDARDS: THE PRINCIPLE OF SUBSIDIARITY

Baltic Journal of Economic Studies, 2023
This article holds considerable significance as it thoroughly analyses the combination of local governance, human rights protection and the implementation of the principle of subsidiarity in Ukraine.
Vitalii Barvinenko, Vadym Hedulianov, Natalia Mishyna   +2 more
doaj   +1 more source