Results 51 to 60 of about 89,677 (261)

Modern Discourse of Human Rights: Main Issues and Contradictions

open access: yesДискурс Пи, 2019
The paper concerns discourses connected with human rights, human rights protection and education in human rights. Authors analyze a number of features that define the development of modern human rights discourses within activity of the UN and the Council
Glushkova S.I., Martynov K.E
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

دراسة مقارنة بين لجنة حقوق الإنسان ومجلس الأمم المتحدة لحقوق الإنسان التشكيل والاختصاصات

open access: yesمجلة الآداب و العلوم الإجتماعية, 2014
The UN was created in 1945 to care for humùan right after the numerous transgressions and crime against humanity. The UN Commission on Human Rightswas set up to preserve international peace. It proved inefficient because it was politcisedand dominated
نرجـس صفو
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Means of the international law council for the protection of human rights [PDF]

open access: yesالرافدین للحقوق
 Human rights and freedoms are the goal of every legal and constitutional.organization, and governments have only existed The human being has the right to the protection of his rights and freedomsHuman rights are an internal matter, but they have ...
Muhammad Alnuiamy
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

STATE SOVEREIGNTY AND PROTECTION OF HUMAN RIGHTS

open access: yesACROSS
This article explores the concept of “state sovereignty” and its transformation into “divided sovereignty” upon a state’s ratification of the European Convention for the Protection of Human Rights and Fundamental Freedoms (hereinafter the Convention).
Stepan POPOVSCHII
doaj   +1 more source

EUROPEJSKA KONWENCJA O PRZYSPOSOBIENIU DZIECI JAKO INSTRUMENT WSPÓLNYCH ZASAD PAŃSTW CZŁONKOWSKICH RADY EUROPY W SPRAWACH O PRZYSPOSOBIENIE DZIECI

open access: yesZeszyty Prawnicze, 2016
The European Convention on the Adoption of Children as an Instrument of the Common Principles of the Member States of the Council of Europe on the Adoption of Children Summary Acting on the grounds of its statutory aims, the Council of Europe has ...
Elżbieta Hanna Morawska
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Towards European Cyber Justice: What Role for the Council of Europe?

open access: yesمجلة القانون، المجتمع والسلطة
Cyber justice and the use of artificial intelligence (AI) in the justice sector are among the core issues to which the Council of Europe devotes significant attention.
Nadia Litim
doaj   +1 more source

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