Results 91 to 100 of about 1,189,722 (360)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Do international human rights treaties improve respect for human rights? [PDF]

After the non-binding Universal Declaration of Human Rights, many global and regional human rights treaties have been concluded. Critics argue that these are unlikely to have made any actual difference in reality.
Eric Neumayer
core  

Letter to Dole Regarding Labor Rights Concerns Surrounding Initial Public Offering [PDF]

, 2009
The recent announcement that Dole will be publicly trading shares motivated the ILRF to raise concerns regarding labor rights and human rights in Dole’s supply chain.
International Labor Rights Forum
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

THE ROLE OF AFRICAN REGIONAL ORGANIZATIONS IN PREVENTION OF HUMAN RIGHTS VIOLATION: A CASE STUDY IN ESWATINI

Turkish International Journal of Special Education and Guidance & Counselling
This paper has addressed the growing wave of unrest in Eswatini and analysed the role of African regional organizations in the prevention of human rights violation.
Naisiligaki LOISIMAYE
doaj  

Russia’s Ministry of Justice Decision to Label 55 Organizations as Extremists: Implications for the Rights of Indigenous Peoples of Russia

Arctic Review on Law and Politics
On 7 June 2024, the Supreme Court of the Russian Federation fulfilled the demand of the Ministry of Justice to label 55 organizations, including those advocating for the rights of Indigenous peoples, as extremists.
Ekaterina Zmyvalova
doaj   +1 more source

Reframing the Immigration Debate: How the Massachusetts Immigrant and Refugee Advocacy Coalition Retooled its Communications Strategy [PDF]

, 2007
This case study chronicles the story of MIRA, the Massachusetts Immigrant and Refugee Advocacy Coalition, and their energetic communications operation.

core  

Human Rights Shaming Through INGOs and Foreign Aid Delivery [PDF]

, 2016
Does the ``shaming" of human rights violations influence foreign aid delivery decisions across OECD donor countries? We examine the effect of shaming, defined as targeted negative attention by human rights international nongovernmental organizations ...
A Alesina, A Alesina, A Brysk, A Dreher, A Dreher, A Murdie, A Murdie, A Murdie, AA Licht, Aitchison, Amanda Murdie, B Bueno de Mesquita, B Page, C Apodaca, C Barry, C Barry, CS Hendrix, D Bond, D Carleton, D Cingranelli, D David, DL Cingranelli, EH Ritter, G Felbermayr, I Kuziemko, J Ausderan, J Ron, J Vreeland, J-S Rioux, JC Franklin, JH Lebovic, L Berger, M Acht, N Bapat, NP Gleditsch, PR Baehr, R Nielsen, R Perkins, S Bennett, S Dietrich, S Dietrich, S Dietrich, Simone Dietrich, T Risse   +43 more
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source