Results 111 to 120 of about 98,472 (314)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Language rights: The forgotten dimension of human rights
, 2011 Over the past sixty years, the notion that language rights might be accorded the status of a fundamental human right and be recognized as such by nation[states and supranational organizations has been both highly contentious and widely contested. The key
May, Stephen
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
, 2013 This thesis explores the ways in which Islamic law and human rights interact within the work of women’s rights non-governmental organizations (NGOs) that advocate the reform of the Egyptian Personal Status Law (PSL) in the period between 2006 and 2010 ...
Sharafeldin, Marwa
core +1 more source
La problemática de los nuevos derechos humanos
Colombia Internacional, 2009 Why are certain problems recognized as human rights issues, while others are not? This article focuses on the political strategies through which marginalized groups transform long standing domestic grievances into internationally-recognized human rights ...
Clifford Bob.
doaj
Human Rights and the Organization of American States
, 1974 The historical idealistic basis of an American community of nations is posited upon the belief that the New World was to be dedicated to liberty, democracy, and peace, in contrast to the monarchy, tyranny, and belligerency which prevailed in the old.1 Since the earliest days of American independence, her leaders have called for respect for and ...
Ann Wynen Van Thomas, A. J. Thomas
openaire +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
ClíoThe state is obliged to fulfill and restore the rights of victims of human rights violations, including victims of the 1965/1966 incident in Palu City. There are five rights that must be fulfilled by victims based on the Basic Principles established by ...
Elfia Farida, Rahayu, Muh Afif Mahfud
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source