Results 121 to 130 of about 1,192,768 (360)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

EL ROL DE LOS ORGANISMOS NO GUBERNAMENTALES DE DERECHOS HUMANOS EN LAS NACIONES UNIDAS

open access: yesRelaciones Internacionales, 2018
En español El representante del Consejo Mundial de Iglesias y del Movimiento Ecuménico por los Derechos Humanos analiza en este trabajo la labor que realizan los Organismos No Gubernamentales de Derechos Humanos desde su incorporación a la Organización ...
Patrick Rise
doaj  

The World Trade Organization and Human Rights

open access: yes, 2009
The authors of this unique publication should be commended for providing a comprehensive interdisciplinary analysis of the new trade and human rights debate. Their most notable achievement is their capacity to clearly demarcate the main parameters of all the legal, social, human and economic dimensions of the interaction between trade liberalisation ...
Joseph, Sarah   +2 more
openaire   +2 more sources

The human right to food as a U.S. nutrition concern, 1976-2006: [PDF]

open access: yes
"For 30 years, U.S. food and nutrition scientists and policymakers concerned with food and nutrition have explored the possibility of making the human right to food (HRF) the moral and legal cornerstone of U.S.
Cohen, Marc J., Messer, Ellen
core  

Fact or Fiction: What Do We Really Know About Human Trafficking? [PDF]

open access: yes, 2011
Statistics form the core of many policies, funding decisions and program designs around human trafficking into forced labor and debt bondage. But are the statistics accurate?
Ann Jordan
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

The Use and Abuse of Human Rights Discourse: A Legitimacy Test for NGOs, IGOs and Governments [PDF]

open access: yes, 2006
Since the end of the Second World War, human rights have emerged as a standard for evaluating state conduct. As the stature of human rights has risen, however, the language and concepts of rights are increasingly misused.
Heinze, Eric
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

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