Results 121 to 130 of about 8,954,431 (357)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
A Cognitive Science Based Machine Learning Architecture [PDF]
In an attempt to illustrate the application of cognitive science principles to hard AI problems in machine learning we propose the LIDA technology, a cognitive science based architecture capable of more human-like learning. A LIDA based software agent or
Baars, Bernard J. +3 more
core +1 more source
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Toward psychiatry as a 'human' science of mind. The case of depressive disorders in DSM-5. [PDF]
Castiglioni M, Laudisa F.
europepmc +1 more source
From pattern appraisal to unitary appreciative inquiry - a critical reflection on the development of the unitary appreciative inquiry method [PDF]
Summative Assessment of the Core Module „Theoretical Developments in the Science and Art of Nursing“. The purpose of this article is to place Cowling’s unitary appreciative inquiry method in the context of nursing science and the development of unique ...
Wolfensberger, Peter
core
Understanding Human-Fire Interactions in Tropical Forest Regions: a Case for Interdisciplinary Research across the Natural and Social Sciences. [PDF]
Rachel Carmenta +4 more
openalex +1 more source
Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Building a Large Dataset of Human-Generated Captions for Science Diagrams [PDF]
Yuri Sato, Ayaka Suzuki, Koji Mineshima
openalex +1 more source

