Results 81 to 90 of about 6,868,150 (311)
Explanation and Understanding Revisited [PDF]
, 2017 "Explanation and Understanding" (1971) by Georg Henrik von Wright is a modern classic in analytic hermeneutics, and in the philosophy of the social sciences and humanities in general.
Raatikainen, Panu
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Case for Investing in Disadvantaged Young Children [PDF]
Bildung, Kinder, Pädagogik, Bildungspolitik, Bildungsinvestition, Education, Children, Education sciences, Educational policy, Human capital ...
James J. Heckman
core
Race in the Life Sciences: An Empirical Assessment, 1950-2000 [PDF]
, 2015 The mainstream narrative regarding the evolution of race as an idea in the scientific community is that biological understandings of race dominated throughout the nineteenth and twentieth centuries up until World War II, after which a social ...
Darling, Katherine +3 more
core +1 more source
Unconventional machine learning of genome-wide human cancer data
, 2020 Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide perspective ...
Bajaj, Sweta R. +7 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Revolutionary Seminary and Human Sciences (Necessity and Actions for Change) [PDF]
سپهر سیاست, 2018 Seminaries have been established with an aim to achieve philosophy of prophethood of the Prophets and to recognize, propagate and safeguard Islam and guidance of men and communities and finally, emergence of Islamic civilizations can regarded as their ...
قاسم ترخان
doaj
Beyond Quality in Early Childhood Education and Care – Languages of Evaluation [PDF]
Bildung, Kinder, Pädagogik, Bildungspolitik, Bildungsinvestition, Education, Children, Education sciences, Educational policy, Human capital ...
Gunilla Dahlberg, Peter Moss
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source