Results 41 to 50 of about 2,507,344 (283)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Phylogeny and molecular dating of the cerato-platanin-encoding genes [PDF]

Genetics and Molecular Biology, 2014
The cerato-platanin family consists of proteins that can induce immune responses, cause necrosis, change chemotaxis and locomotion and may be related to the growth and development of various fungi. In this work, we analyzed the phylogenetic relationships
Hanying Yu, Lin Li
doaj   +3 more sources

Editorial Volume 12

Journal of Human Security, 2016
Dear Reader,As I write this first official reports confirm the existence of gravitational waves which Albert Einstein predicted a century ago. Ground breaking scientific discoveries such as this reaffirm to me the spatial relationships between the ...
Sabina Lautensach
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

ORBITaL-Net: A labeled training library for large-scale building feature extraction

Scientific Data
Over the course of several years, nearly 1.5 million building outlines have been created from approximately 128,000 training tiles covering roughly 7,000 km 2 of very high-resolution multispectral overhead imagery, primarily dated between 2010 and 2020 ...
Benjamin Swan, Joe Pyle, Darrell Roddy, H. Lexie Yang, Amy Rose, Melanie Laverdiere   +5 more
doaj   +1 more source

Ecosystem and disaster risk: A review of ecological indicators in the context of disaster risk assessments and discussion of their usefulness to inform ecosystem health

Nature-Based Solutions
Ecosystems play a critical role in reducing disaster risk by providing ecosystem services (ESS) that influence all components of risk. The capacity to deliver ESS depends on the health of the ecosystem itself. Thus, it is key to consider ecosystem health
S. Janzen, L. Narvaez, A. Ortiz-Vargas, J. O‘Connor, Y. Walz, Z. Sebesvari   +5 more
doaj   +1 more source

Women's autonomy and food security: Connecting the dots from the perspective of Indigenous women in rural Colombia

SSM: Qualitative Research in Health, 2022
There is a growing consensus that women's autonomy is positively related to food security. However, the evidence is inconsistent, and the nature of the pathways connecting the two factors remains unclear.
Kate Sinclair, Theresa Thompson-Colón, Alexandra Milena Bastidas-Granja, Sara Eloísa Del Castillo Matamoros, Eucaris Olaya, Hugo Melgar-Quiñonez   +5 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Building morphologies of the USA structures database; a gauntlet feature set

Scientific Data
In recent years there has been a proliferation of methods and data to extract building footprints from satellite imagery. However there has been very little effort to provide additional insight about these buildings beyond their spatial location and ...
Taylor Hauser, Clinton Stipek, Nagendra Singh, Jessica Moehl   +3 more
doaj   +1 more source

Editorial Volume 14

Journal of Human Security, 2018
Dear Reader, “Are we nuts?“ asked recently one of my favourite bloggers. She was referring to human behaviour that contravened the actor’s own explicit interests, as routinely reported in a cross-section of the average daily news.
Sabina Lautensach
doaj   +1 more source