Results 51 to 60 of about 2,507,344 (283)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Mindset shifts and sustainability transformation journeys across Urban Labs in Latin America

open access: yesUrban Transformations
Cities are at the forefront of the climate crisis, requiring innovative approaches to foster sustainability transformations. Urban Labs offer a promising avenue for engaging diverse stakeholders and driving transformative change, yet the role of mindset ...
Flávia Guerra   +3 more
doaj   +1 more source

Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy

open access: yesNature Communications, 2023
COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these are administered as combinations e.g.
Manon Ragonnet-Cronin   +25 more
doaj   +1 more source

Redefining Human Security The Case of Albania [PDF]

open access: yes, 2016
This paper offers a critical study of the concept and issues of human security. Its usage, definition and applicability may differ since different authors explain issues related to security differently.
Farruku, Eglantina
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Pervasive eHealth services a security and privacy risk awareness survey [PDF]

open access: yes, 2016
The human factor is often recognised as a major aspect of cyber-security research. Risk and situational perception are identified as key factors in the decision making process, often playing a lead role in the adoption of security mechanisms.
Bellekens, Xavier   +5 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Moving towards a comprehensive evaluation of ecosystem-based disaster risk reduction: The example of agroforestry for flood risk reduction

open access: yesNature-Based Solutions
Nature-based solutions (NbS) have received increased interest as cost-effective contributors to addressing societal challenges, with ecosystem-based disaster risk reduction (Eco-DRR) being the specific approach for reducing disaster risk under the NbS ...
S. Janzen   +5 more
doaj   +1 more source

Synergies and trade-offs in the management objectives forest health and flood risk reduction

open access: yesFrontiers in Forests and Global Change, 2023
While healthy forest ecosystems deliver various services that can reduce flood risk, they can also contribute to flooding by providing wood that potentially contributes to the clogging of waterways and associated backwater effects.
Fabian Rackelmann   +3 more
doaj   +1 more source

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