Results 41 to 50 of about 294,711 (260)

Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy

Nature Communications, 2023
COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these are administered as combinations e.g.
Manon Ragonnet-Cronin, Rungtiwa Nutalai, Jiandong Huo, Aiste Dijokaite-Guraliuc, Raksha Das, Aekkachai Tuekprakhon, Piyada Supasa, Chang Liu, Muneeswaran Selvaraj, Natalie Groves, Hassan Hartman, Nicholas Ellaby, J. Mark Sutton, Mohammad W. Bahar, Daming Zhou, Elizabeth Fry, Jingshan Ren, Colin Brown, Paul Klenerman, Susanna J. Dunachie, Juthathip Mongkolsapaya, Susan Hopkins, Meera Chand, David I. Stuart, Gavin R. Screaton, Sakib Rokadiya   +25 more
doaj   +1 more source

Mapping Childhood Cancer Care Services in Oceania: Methodological Lessons From the SIOP Global Mapping Programme

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The International Paediatric Oncology Society Global Mapping Programme aims to collect data on global paediatric oncology services by continent, with Africa and Latin America completed. This study reports on the methodology and lessons learned for Oceania, a unique continent with resource disparity across countries, multiple small island ...
Trisha Soosay Raj, Christy Noble, Amy Gray, Daniel C. Moreira, Jennifer Lowe, Maite Gorostegui, Gwenda Anga, Andrew Soma, Milena Lay Dos Santos, Siobhan Cross, Erin Luttrell, Michael Sullivan, Julie Cayrol, Julia Challinor, Neil Ranasinghe, Jordana McLoone, Claire E. Wakefield   +16 more
wiley   +1 more source

A vulnerability perspective on loss and damage: evidence from urban informal settlements

npj Urban Sustainability
The scientific evidence on climate-related losses and damages is steadily increasing. However, the experiences of people living in urban areas, including informal settlements, are largely absent from research and policy.
Douwe van Schie, Simone Sandholz, Lucas Turmena, Nabiyya Perennia, Syed Muhammad Jaffar Abbas, Philip Bonera Bananayo, Magdalena Mirwald, Kees van der Geest   +7 more
doaj   +1 more source

Ecosystem and disaster risk: A review of ecological indicators in the context of disaster risk assessments and discussion of their usefulness to inform ecosystem health

Nature-Based Solutions
Ecosystems play a critical role in reducing disaster risk by providing ecosystem services (ESS) that influence all components of risk. The capacity to deliver ESS depends on the health of the ecosystem itself. Thus, it is key to consider ecosystem health
S. Janzen, L. Narvaez, A. Ortiz-Vargas, J. O‘Connor, Y. Walz, Z. Sebesvari   +5 more
doaj   +1 more source

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source

Human Security or National Security: the Problems and Prospects of the Norm of Human Security

Journal of Politics and Law, 2008
The emergence of the norm of human security prioritizes individuals’ security over national security and conceptualizes poverty as the real threat to the security of individuals. Therefore, it urges for more attention to sustainable development as the functional strategy to ensure human security.
Hasan Mahmud, Muhammad Mahbub Quaisar, Md. Abdus Sabur, Sharmin Tamanna   +3 more
openaire   +1 more source

ORBITaL-Net: A labeled training library for large-scale building feature extraction

Scientific Data
Over the course of several years, nearly 1.5 million building outlines have been created from approximately 128,000 training tiles covering roughly 7,000 km 2 of very high-resolution multispectral overhead imagery, primarily dated between 2010 and 2020 ...
Benjamin Swan, Joe Pyle, Darrell Roddy, H. Lexie Yang, Amy Rose, Melanie Laverdiere   +5 more
doaj   +1 more source

Barriers and enablers of green development: the example of blue economy sectors in coastal communities of the Wadden Sea region

Frontiers in Ocean Sustainability
Climate change and human activities are altering marine and coastal ecosystems, threatening biodiversity, ecosystem services, and livelihoods. The blue economy depends on healthy ecosystems but also drives their degradation.
Josepha Nestele, Lisa Hartmann, Yvonne Walz   +2 more
doaj   +1 more source

Determinants of child anthropometric indicators in Ethiopia

BMC Public Health, 2018
Background Malnutrition is one of the major contributors to child mortality in Ethiopia. Currently established, child nutrition status is assessed by four anthropometric indicators.
Davod Ahmadi, Ekta Amarnani, Akankasha Sen, Narges Ebadi, Patrick Cortbaoui, Hugo Melgar-Quiñonez   +5 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source