Results 131 to 140 of about 426,418 (303)

Optimization Design Method of Pipe-Insulating Joints Based on Surrogate Model and Genetic Algorithm

open access: yesApplied Sciences
Pipe-insulating joints are common cathodic protection devices in long-distance oil and gas pipeline infrastructures. To ensure safety, they are often designed too conservatively, resulting in large dimensions, high self-weight, and substantial costs ...
Chen Guo   +5 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Assessing the Impact of Ambient Noise on Outdoor Thermal Comfort on University Campuses: A Pilot Study in China’s Cold Region

open access: yesAtmosphere
This study investigates the impact of different noise levels on thermal comfort in outdoor environments. The research was conducted in two university squares in Xi’an, China, exhibiting distinct noise exposures, with twenty volunteers participating in ...
Shaobo Ning   +3 more
doaj   +1 more source

Culture and Human Settlements

open access: yes, 2019
{"references": ["Belshek, Jalal Ali 2006, The influence of culture on the negotiation styles of British students, http://research.ncl.ac.uk/ARECLS/volume_3/jalalali.pdf", "http://www.cssforum.com.pk/css-optional-subjects/group-b/sociology/8613-various-definitions-culture.html", "http://www.theperfectworld.org/the%20climate.html", "Kroeber, AL & ...
openaire   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Research on Planning Strategy for Urban Community Living Environment for the Elderly That Promotes “Living Mutual Aid”

open access: yesBuildings
With the development of urban population aging in China, enhancing the quality of community living environments for the elderly has become crucial. Traditional residential planning focused on functionality, neglecting the elderly’s active participation ...
Tianye Liu   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

A Wind Protection Design Strategy for Airport Terminal Door Bucket Space Based on Wind Environment Simulations

open access: yesBuildings
Airport terminal buildings are large public transportation buildings with complex functions and dense crowds, and the wind environment has significant effects on passenger comfort and the energy consumption of air conditioning systems.
Lu Yang   +3 more
doaj   +1 more source

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