Results 41 to 50 of about 427,819 (300)
Assessing texture pattern in slum across scales: an unsupervised approach [PDF]
, 2005 According to the Global Report on Human Settlements (United Nations, 2003), almost 1 billion people (32% of the world ’s population) live in squatter settlements or slums.
Barros Filho, M., Sobreira, F.
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Sunlight perception and outdoor thermal comfort in college campuses: a new perspective
Scientific Reports, 2023 The thermal comfort of outdoor spaces in colleges and universities is crucial for promoting outdoor activities and relieving psychological pressure. To evaluate outdoor thermal comfort from a new perspective, this study investigated subjects' sunlight ...
Shaobo Ning, Wenqiang Jing, Zhemin Ge
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Research on Shield Tunneling across a River Using a Scale Model
Buildings, 2023 This paper proposes a scale model test to simulate shield tunnel excavation over long distances. The test simulates the whole process of shield tunneling through the Weihe River on Xi’an Metro Line 1, where the tunneling length and diameter reach 100 m ...
Wenxiao Li +3 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
International Journal for Equity in HealthBackground Accommodating chronic care into the everyday lives of individuals diagnosed with non-communicable chronic conditions often poses significant challenges.
Nilanjan Bhor, P Omkar Nadh
doaj +1 more source
Geospatial multi-criteria analysis for identifying high priority clean energy investment opportunities: A case study on land-use conflict in Bangladesh [PDF]
, 2019 Bangladesh is a globally important emerging economy with rapidly increasing energy demand. The Bangladeshi government's primary capacity expansion plan is to install 13.3 GW of new coal by 2021, including the 1.3 GW Rampal coal power plant to be ...
Kammen, DM, Shiraishi, K, Shirley, RG
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source