Results 41 to 50 of about 56,323 (263)

Optimization of indoor quality and thermal comfort for university classrooms using data-based machine learning [PDF]

E3S Web of Conferences
Improving indoor environment quality on university classrooms is a hot research topic. The on-site experiment was conducted on indoor environmental quality regarding temperature, humidity, air pollutants, light and acoustics during different seasonal ...
Jiang Qiwen, Liu Jialu, Yang Xian
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Inter-provincial water-energy-carbon transfer and its efficiency in China: the perspective of land use

Carbon Balance and Management
Background Revealing inter-regional water-energy-carbon transfer driven by land use has great significance for realizing multiple objectives of resource collaborative optimization and carbon mitigation, yet land-use WEC accounting at the provincial scale
Chen Cai, Rongqin Zhao, Hanbing Li, Liangang Xiao, Zhixiang Xie, Wei Wu, Jiayu Ji, Qianhu Xiao   +7 more
doaj   +1 more source

Soil pH and Nitrogen Content Drive the Succession of RubisCO-Harboring Microbial Communities Across Picea asperata Plantation Ages

Biology
Autotrophic carbon-fixing microbes can assimilate atmospheric carbon dioxide into biomass via the Calvin–Benson–Bassham (CBB) cycle (their primary carbon fixation pathway), thereby reinforcing soil carbon sequestration in the plantation ecosystem ...
Dehui Li, Yaodan Deng, Xiaohui Zhao, Qian Liao, Jialing Chen, Chaonan Li, Haijun Liao   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

BresNet: Applying Residual Learning in Backpropagation Neural Networks to Predict Ground Surface Concentration of Primary Air Pollutants

Remote Sensing
Monitoring air pollution is important for human health and the environment. Previous studies on the prediction of air pollutants from satellite images have employed machine learning, yet there are few enhancements to the constructure of model.
Zekai Shi, Meng Zhang, Mei Han, Yaowei Zhang, Guodong Ma, Haoyuan Ren   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Utilization of Thermal-Activated Coal Gangue to Enhance the Properties of Sandy Soil Composites

Applied Sciences
To effectively solve the problem of land sanding and improve the water- and element-retaining properties of sandy soil, a thermal-activated coal gangue (TACG) was used as an ameliorating material to prepare a composite soil mixed with sandy soil to ...
Wangtao Fan, Ruofan Liu, Runxia Zhang, Xiaoguang Chen, Jin Li, Aochen Zhang, Jing Qian, Zhaolin Gu, Jianyun Wang   +8 more
doaj   +1 more source