Results 41 to 50 of about 7,638,508 (295)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Improved governance and sustainable urban development Strategic planning holds the key

European Journal of Spatial Development, 2006
The recent focus on improved governance in cities has raised some concerns about the role of urban planning. Questions have been raised on whether good governance is a substitute for planning, and if it is adequate in itself to achieve sustainable ...
Shipra Narang, Lars Reuterswärd
doaj   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Interfaces of ‘being healthy and being Ill’: how is health being perceived by individuals with non-communicable chronic conditions?

International Journal for Equity in Health
Background Accommodating chronic care into the everyday lives of individuals diagnosed with non-communicable chronic conditions often poses significant challenges.
Nilanjan Bhor, P Omkar Nadh
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Women's access to land and housing post-1994 in the informal settlements at Ficksburg in the Free State South Africa [PDF]

, 2010
This dissertation investigated the constraints that inhibit women from getting access to formal housing and land in Ficksburg in the Free State province of South Africa.
Kane, Mookho
core   +1 more source

Multi-scenario simulation of land-use conflicts in China’s major grain-producing regions

Humanities & Social Sciences Communications
Food security is a strategic issue of global concern. In China’s major grain-producing regions (CMGPRs), conflicts among agricultural, construction, and ecological land are intensifying due to rapid urbanization and overlapping land-use demands ...
Wenting Fan, Jun Yang, Zhe Li, Xuefeng Kang, Yuqing Zhang, Xinyao Tai, Jiyao Liu, Xiangming Xiao, Jianhong Cecilia Xia   +8 more
doaj   +1 more source

Optimization of indoor quality and thermal comfort for university classrooms using data-based machine learning [PDF]

E3S Web of Conferences
Improving indoor environment quality on university classrooms is a hot research topic. The on-site experiment was conducted on indoor environmental quality regarding temperature, humidity, air pollutants, light and acoustics during different seasonal ...
Jiang Qiwen, Liu Jialu, Yang Xian
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source