Results 71 to 80 of about 7,638,508 (295)

Increasing resilience of the education system to climate change impacts in the Eastern Caribbean region

, 2019
The objective of this project/programme is increasing resilience of the education system to climate change impacts in the Eastern Caribbean region namely Antigua and Barbuda, the Commonwealth of Dominica and St Lucia.
United Nations Human Settlements Programme
core   +1 more source

Research on Optimization Design Strategies for Natural Ventilation in Living Units of Institutional Elderly Care Facilities Based on Computational Fluid Dynamics Simulation

Buildings
As China transitions into a deeply aging society, the elderly population’s growth has driven a rapid increase in elderly care institutions and facilities during the “13th Five-Year Plan” period, rising by over 235% compared to the “12th Five-Year Plan ...
Tianye Liu, Jingxian Wang, Dian Zhou, Xiangzhao Meng, Xilian Luo, Yupeng Wang   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Latin American and Caribbean Regional Plan of Action on Human Settlements

, 2011
http://www.cepal.org/pobrezaurbana/docs/minurvi/IXForo/PlanofactiononHumanSettlements.pdfDeals with achieving social equity and alleviating urban poverty; the productivity of human settlements for improving the quality of life; improving the environment ...
UN ECLAC
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Biochar-Based Remediation of Heavy Metal-Contaminated Soils: Mechanisms, Synergies, and Sustainable Prospects

Nanomaterials
This study systematically explores the mechanisms and application potential of biochar in remediating heavy metal-contaminated soils. Particular emphasis is placed on the role of raw materials and pyrolysis conditions in modulating key physicochemical ...
Yuxin Wei, Jingjing Ma, Kuankuan Liu, Shuai Zhang, Junqi Wang   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Characteristics of organic contaminant removal from nickel soap wastewater via a photocatalytic Fenton oxidation-coagulation coupling process

Gongye shui chuli
A nickel soap wastewater-based photocatalytic Fenton oxidation-coagulation coupling process was developed to enhance the removal efficiency of organic pollutants and overcome the limitations of conventional Fenton processes.
QI Yuetong, XU Lu, Wei Xiaojia, JIN Xin, BAI Xue, SHI Xuan, HUANG Yue, JIN Pengkang   +7 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Provincial allocation of carbon emission quotas for China’s 2030 carbon peak target

Carbon Balance and Management
Developing a fair and effective carbon emissions quotas (CEQ) allocation plan is crucial for China. This study uses the constructed threshold-STIRPAT extended model to predict the carbon peak in China’s 30 provinces.
Ning Wang, Jin Li, Zhongke Qu, Hui Xi, Yang Zhang, Zhanjun Wang, Zhaolin Gu   +6 more
doaj   +1 more source