Results 121 to 130 of about 9,029,134 (304)

Skeletal muscle patch engineering on synthetic and acellular human skeletal muscle originated scaffolds

Journal of Biomedical Materials Research Part A, 2016
AbstractThe reconstruction of skeletal muscle tissue is currently performed by transplanting a muscle tissue graft from local or distant sites of the patient's body, but this practice leads to donor site morbidity in case of large defects. With the aim of providing an alternative treatment approach, skeletal muscle tissue formation potential of human ...
Ay, Birol, Karaoz, Erdal, Kesemenli, Cumhur C., Kenar, Halime   +3 more
openaire   +4 more sources

Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly During Tissue Repair

Advanced Materials, EarlyView.
This study reports on the chemical modification of hyaluronic acid to create hydrogels with hydrolytic degradability ranging from 2–28 days. Granular hydrogels that undergo timed degradation to increase porosity enhance cell invasion and provisional ECM remodeling in a muscle injury model, leading to reduced fibrosis and improved regeneration ...
Zhiyuan Chen, Tuba Marjan, Xinyue Lu, Nicole E. Mertens, Keira Vesy, Dean E. Stornello, James F. Markworth, Taimoor H. Qazi   +7 more
wiley   +1 more source

OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development

Skeletal Muscle
Background Highly expressed in skeletal muscles, the gene Obscurin (i.e. OBSCN) has 121 non-overlapping exons and codes for some of the largest known mRNAs in the human genome.
Ali Oghabian, Per Harald Jonson, Swethaa Natraj Gayathri, Mridul Johari, Ella Nippala, David Gomez Andres, Francina Munell, Jessica Camacho Soriano, Maria Angeles Sanchez Duran, Juha Sinisalo, Heli Tolppanen, Johanna Tolva, Peter Hackman, Marco Savarese, Bjarne Udd   +14 more
doaj   +1 more source

Human skeletal muscle aging atlas

Nature Aging
Abstract Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in ...
Veronika R. Kedlian, Yaning Wang, Tianliang Liu, Xiaoping Chen, Liam Bolt, Catherine Tudor, Zhuojian Shen, Eirini S. Fasouli, Elena Prigmore, Vitalii Kleshchevnikov, Jan Patrick Pett, Tong Li, John E. G. Lawrence, Shani Perera, Martin Prete, Ni Huang, Qin Guo, Xinrui Zeng, Lu Yang, Krzysztof Polański, Nana-Jane Chipampe, Monika Dabrowska, Xiaobo Li, Omer Ali Bayraktar, Minal Patel, Natsuhiko Kumasaka, Krishnaa T. Mahbubani, Andy Peng Xiang, Kerstin B. Meyer, Kourosh Saeb-Parsy, Sarah A. Teichmann, Hongbo Zhang   +31 more
openaire   +2 more sources

Superpulsed low-level laser therapy protects skeletal muscle of mdx mice against damage, inflammation and morphological changes delaying dystrophy progression. [PDF]

, 2014
Aim: To evaluate the effects of preventive treatment with low-level laser therapy (LLLT) on progression of dystrophy in mdx mice. Methods: Ten animals were randomly divided into 2 experimental groups treated with superpulsed LLLT (904 nm, 15 mW, 700 Hz ...
de Carvalho, Paulo de Tarso Camillo, Leal-Junior Ernesto Cesar Pinto, Lucio Frigo, Patrícia de Almeida, Lopes-Martins, Rodrigo Alvaro Brandao, de Almeida, Patrícia, Joensen Jon, Tomazoni, Shaiane Silva, Tomazoni Shaiane Silva, Bjordal, JM, Leal, Ernesto Cesar Pinto Jr, Leal-Junior, EC, Lopes-Martins, R, Joensen, J, Johnson, Mark I., Lopes-Martins Rodrigo Álvaro Brandão, Frigo, Lúcio, Paulo de Tarso Camillo de Carvalho, Tomazoni, SS, Bjordal, Jan Magnus, Bjordal Jan Magnus, Johnson, MI, Jon Joensen, Rodrigo Álvaro Brandão Lopes-Martins, de Carvalho, PT, Mark I Johnson, Ernesto Cesar Pinto Leal-Junior, Joensen, Jon, de Almeida, P, Frigo, L, Jan Magnus Bjordal, Frigo Lucio, Johnson Mark I., de Carvalho Paulo de Tarso Camillo, de Almeida Patrícia, Shaiane Silva Tomazoni   +35 more
core   +2 more sources

Bilayered PEDOT:PSS–Collagen Scaffolds as Functional Architectures for Tissue Engineering

Advanced Materials Interfaces, EarlyView.
A bilayered scaffold integrates collagen and PEDOT:PSS as distinct yet interconnected 3D matrices, preserving their fibrillar and conductive characteristics. Spatial compartmentalization enables independent tailoring of each domain while maintaining mechanical stability and compatibility with electrochemical monitoring, providing a multifunctional ...
Rasha Nasser, Jiranuwat Sapudom, Sotiris Psilodimitrakopoulos, Emmanuel Stratakis, Jeremy Teo, Vincent Chan, Charalampos Pitsalidis   +6 more
wiley   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

Organoids as Building Blocks for Adaptive and Resilient Biohybrid Robots

Advanced Materials Technologies, EarlyView.
ABSTRACT Biohybrid robots combine engineered living tissues with synthetic materials and have emerged as a promising class of soft robotic systems capable of mimicking biological functions such as biodegradability, energy efficiency and flexible motions. By integrating biological and synthetic components, these systems leverage complementary properties
Antonia Georgopoulou
wiley   +1 more source

Soft Actuators Integrated with Control and Power Units: Approaching Wireless Autonomous Soft Robots

Advanced Robotics Research, EarlyView.
Soft robots exhibit significant development potential in various applications. However, there are still key technical challenges regarding material improvement, structure design and components integration. This review focuses on the development and challenge of soft actuators, power components, and control components in untethered intelligent soft ...
Renwu Shi, Feifei Pan, Xiaobin Ji
wiley   +1 more source

Liquid Crystalline Elastomers in Soft Robotics: Assessing Promise and Limitations

Advanced Robotics Research, EarlyView.
Liquid crystalline elastomers (LCEs) are programmable soft materials that undergo large, anisotropic deformation in response to external stimuli. Their molecular alignment encodes directional actuation in a monolithic structure, making them long‐standing candidates for soft robotic systems.
Justin M. Speregen, Timothy J. White
wiley   +1 more source