Results 201 to 210 of about 976,647 (347)

Delineating transcriptomic signatures of in vitro human skeletal muscle models in comparison to in vivo references. [PDF]

Stem Cell Reports
Van Puyvelde M, Mohammed EE, Anguita ÁM, Bonroy J, Jansen S, Yilmaz A.   +5 more
europepmc   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Lamin A/C protects chromatin accessibility during mechanical loading in human skeletal muscle. [PDF]

Cell Commun Signal
Jabre S, Cherchame E, Pinzón N, Lemerle E, Bitoun M, Coirault C.   +5 more
europepmc   +1 more source

Understanding the Role of ECM Protein Composition and Geometric Micropatterning for Engineering Human Skeletal Muscle

Annals of Biomedical Engineering, 2016
Rebecca M. Duffy, Yan Sun, A. Feinberg
semanticscholar   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Effects of habitual endurance and resistance exercise on insulin action in primary human skeletal muscle stem cells. [PDF]

Physiol Rep
Krassovskaia P, Jevtovic F, Zheng D, Noone J, Yeo RX, Pino MF, Stowe CL, Emilson SS, Musi N, Huffman KM, Hebert C, Bowen S, Zarini S, Ravussin E, Broskey NT, Krauss WE, Bergman BC, Sparks L, Houmard JA.   +18 more
europepmc   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

Extensive differential gene expression and regulation by sex in human skeletal muscle. [PDF]

Cell Genom
Hanks SC, Mauger AS, Varshney A, Ciotlos DL, Manickam N, Narisu N, Shumway AJ, Orchard P, Erdos MR, Sweeney MD, Okamoto J, Jackson AU, Stringham HM, Bonnycastle LL, Zhou X, Lakka TA, Mohlke KL, Tuomilehto J, Laakso M, Boehnke M, Sethupathy P, Collins FS, Koistinen HA, Parker SCJ, Scott LJ.   +24 more
europepmc   +1 more source

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

Aerobic and resistance exercise-regulated phosphoproteome and acetylproteome modifications in human skeletal muscle. [PDF]

Nat Commun
Pataky MW, Heppelmann CJ, Sevits KJ, Asokan AK, Kumar AP, Klaus KA, Dasari S, Kunz HE, Strub MD, Robinson MM, Coon JJ, Lanza IR, Adams CM, Nair KS.   +13 more
europepmc   +1 more source