Results 181 to 190 of about 9,029,134 (304)

The circadian clock component NPAS2 is modulated by AMPK and regulates substrate utilization and mitochondrial function in human skeletal muscle cells. [PDF]

Mol Metab
Rizo-Roca D, Pendergrast LA, Kamble P, Guimarães DSPSF, Dollet L, Björnholm M, Zierath JR.   +6 more
europepmc   +1 more source

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

Advanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu, Frank Daniel Peters, Haokang Zhang, Madison Stiefbold, Thangam Ramar, Aditya Agarwal, Leo Q. Wan   +6 more
wiley   +1 more source

Single-Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity During Human Skeletal Muscle Aging. [PDF]

Aging Cell
Gong C, Wu L, Wang A, Hua N, Qin C, Huang S, Zhang X, Yang Y, Chen J, Zhang Q.   +9 more
europepmc   +2 more sources

Transcriptional remodeling of human skeletal muscle following sleep restriction in postmenopausal women. [PDF]

Physiol Genomics
Suryadevara HNSK, Hebert RC, Staszkiewicz J, Ravussin E, Marlatt KL, Singh P, Ghosh S.   +6 more
europepmc   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

Fractionated proteomics identifies a protein network mitigating resistance exercise-induced damage in human skeletal muscle. [PDF]

Nat Commun
Kuppusamy M, Jacko D, Gupta Y, Sieger S, Schaaf K, Matijass M, Bersiner K, Zacher J, Bonini S, Cosenza-Contreras M, van der Ven P, Bloch W, Fürst DO, Winter D, Höhfeld J, Huesgen PF, Gehlert S.   +16 more
europepmc   +1 more source

SLC25A4high Hepatocytes Enhance Lifestyle Intervention Response in MASLD by Recruiting Eating Macrophages

Advanced Science, EarlyView.
SLC25A4high hepatocytes drive metabolic‐associated steatotic liver disease (MASLD) remission by recruiting lipid‐eating macrophages. The hepatocyte Slc25a4/PANX1/ATP/P2ry12 axis mediates find‐me signaling that triggers macrophage recruitment and efferocytosis, while recruited macrophages secrete GDF15 to activate hepatocyte PPARα and promote fatty acid
Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang   +8 more
wiley   +1 more source

Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle fiber-type gene expression. [PDF]

iScience
Ciotlos DL, Hanks SC, Varshney A, Erdos MR, Manickam N, Stringham HM, Orchard P, Hill-Burns EM, Narisu N, Bonnycastle LL, Sweeney MD, Saramies J, Laakso M, Tuomilehto J, Lakka TA, Mohlke KL, Boehnke M, Collins FS, Koistinen HA, Parker SCJ, Scott LJ.   +20 more
europepmc   +1 more source

Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications

Advanced Science, EarlyView.
Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu, Xingyun Liu, Fangzhou Wang, Huili Ren, Chaojun Zhang, Ziyu Ren, Zunqi Liu, Jing Li   +7 more
wiley   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source