Results 51 to 60 of about 976,647 (347)

Aerobic and resistance exercise training reverses age‐dependent decline in NAD+ salvage capacity in human skeletal muscle

Physiological Reports, 2019
Aging decreases skeletal muscle mass and strength, but aerobic and resistance exercise training maintains skeletal muscle function. NAD+ is a coenzyme for ATP production and a required substrate for enzymes regulating cellular homeostasis.
Roldan M. de Guia, Marianne Agerholm, T. Nielsen, L. Consitt, Ditte Søgaard, J. Helge, S. Larsen, J. Brandauer, J. Houmard, J. T. Treebak   +9 more
semanticscholar   +1 more source

Pathological Mechanism of a Constitutively Active Form of Stromal Interaction Molecule 1 in Skeletal Muscle

Biomolecules, 2021
Stromal interaction molecule 1 (STIM1) is the main protein that, along with Orai1, mediates store-operated Ca2+ entry (SOCE) in skeletal muscle. Abnormal SOCE due to mutations in STIM1 is one of the causes of human skeletal muscle diseases.
Ji Hee Park, Seung Yeon Jeong, Jun Hee Choi, Eun Hui Lee   +3 more
doaj   +1 more source

Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise [PDF]

, 2016
Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle performance, maintaining metabolic function and supporting longevity and healthspan.
Goto S, NICE, Ntanasis‐Stathopoulos J, Rantanen T, Wilson SJ   +4 more
core   +1 more source

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia [PDF]

, 2020
Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured.
Bonetto, Andrea, Huot, Joshua R., Novinger, Leah J., Pin, Fabrizio   +3 more
core   +1 more source

The ERG1A K⁺ Channel Is More Abundant in Rectus abdominis Muscle from Cancer Patients Than that from Healthy Humans

Diagnostics, 2021
Background: The potassium channel encoded by the ether-a-gogo-related gene 1A (erg1a) has been detected in the atrophying skeletal muscle of mice experiencing either muscle disuse or cancer cachexia and further evidenced to contribute to muscle ...
Sandra Zampieri, Marco Sandri, Joseph L. Cheatwood, Rajesh P. Balaraman, Luke B. Anderson, Brittan A. Cobb, Chase D. Latour, Gregory H. Hockerman, Helmut Kern, Roberta Sartori, Barbara Ravara, Stefano Merigliano, Gianfranco Da Dalt, Judith K. Davie, Punit Kohli, Amber L. Pond   +15 more
doaj   +1 more source

Age- and activity-related differences in the abundance of Myosin essential and regulatory light chains in human muscle [PDF]

, 2016
Traditional methods for phenotyping skeletal muscle (e.g., immunohistochemistry) are labor-intensive and ill-suited to multixplex analysis, i.e., assays must be performed in a series. Addressing these concerns represents a largely unmet research need but
Burniston, Jatin G., Close, Graeme L., Cobley, James N., Edwards, Ben J., Malik, Zulezwan Ab., Morton, James P.   +5 more
core   +4 more sources

Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice

Journal of Sport and Health Science
Background: Exercise is an effective intervention for obesity and type 2 diabetes, with significant physiological benefits over pharmacological interventions.
Robert J. Shute, Ryan N. Montalvo, Wenqing Shen, Yuntian Guan, Qing Yu, Mei Zhang, Zhen Yan   +6 more
doaj   +1 more source

Evidence that muscle cells do not express the histidine-rich glycoprotein associated with AMP deaminase but can internalise the plasma protein

European Journal of Histochemistry, 2011
Histidine-rich glycoprotein (HRG) is synthesized by liver and is present at relatively high concentration in the plasma of vertebrates. We have previously described the association of a HRG-like molecule to purified rabbit skeletal muscle AMP deaminase ...
A.R.M. Sabbatini, L. Mattii, B. Battolla, E. Polizzi, D. Martini, M. Ranieri-Raggi, A.J.G. Moir, A. Raggi   +7 more
doaj   +1 more source

Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy [PDF]

, 2018
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by ...
Díaz Manera, Jordi, Escudero Cuadrado, Luis María, Fernández Simón, Esther, Gallardo, Eduard, Gómez Gálvez, Pedro, Piñol Jurado, Patricia, Suárez Calvet, Xavier   +6 more
core   +1 more source

Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle.

JCI Insight, 2018
BACKGROUND Accumulation of diacylglycerol (DAG) and sphingolipids is thought to promote skeletal muscle insulin resistance by altering cellular signaling specific to their location.
L. Perreault, S. Newsom, Allison Strauss, Anna A. Kerege, D. Kahn, K. Harrison, J. Snell-Bergeon, T. Nemkov, A. D’Alessandro, M. Jackman, P. MacLean, B. Bergman   +11 more
semanticscholar   +1 more source